ATAD2 and E2F4

Number of citations of the paper that reports this interaction (PMID 20855524)
12

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATAD2	E2F4
Gene Name		ATPase family, AAA domain containing 2	E2F transcription factor 4, p107/p130-binding
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Extracellular Vesicular Exosome	Nucleoplasm Transcription Factor Complex
	Molecular Function	ATP Binding ATPase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding
	Biological Process	Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Epithelial Cell Development Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Volume Homeostasis Transforming Growth Factor Beta Receptor Signaling Pathway Blood Circulation Regulation Of Cell Size Organ Morphogenesis Gene Expression Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription From RNA Polymerase II Promoter Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways			Loss of Function of TGFBR2 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway Mitotic G1-G1/S phases TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer G1 Phase Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer G0 and Early G1 Loss of Function of TGFBR1 in Cancer Cell Cycle, Mitotic Cyclin D associated events in G1 Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: E2F1 E2F2 E2F3 E2F4 ESR1 HIST2H4A HIST3H3 MYC NCOA3	25 interactors: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A FHL2 HCFC1 ID3 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		29028	1874
HPRD ID		10678	02806
Ensembl ID		ENSG00000156802	ENSG00000205250
Uniprot IDs		Q6PL18	Q16254
PDB IDs		3DAI	1CF7
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Lens Fiber Cell Apoptotic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Fibroblast Proliferation Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Cell Cycle RNA Biosynthetic Process Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Fibroblast Proliferation Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Vagina Development Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Female Genitalia Development Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Remodeling Chromatin Modification Branching Morphogenesis Of An Epithelial Tube Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Homeostatic Process Morphogenesis Of A Branching Epithelium Chromatin Organization Morphogenesis Of A Branching Structure Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Cell Proliferation Genitalia Development Mammary Gland Duct Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transcription, DNA-templated Response To Transforming Growth Factor Beta Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process DNA-templated Transcription, Initiation Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Cell Cycle Process Regulation Of Centrosome Duplication Androgen Receptor Signaling Pathway Regulation Of Centrosome Cycle Negative Regulation Of Centriole Replication
Tagcloud ?		acted ancca budding bulk compaction deviations dosage driver entering facilitating hta1 internucleosomal locally metagene nucleosomal nucleosome nucleosomes ortholog profound progressively reflected rtt106 shifted shifts spacing transcriptionally ways yta7 yta7delta	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Difference) ?		acted ancca budding bulk compaction deviations dosage driver entering facilitating hta1 internucleosomal locally metagene nucleosomal nucleosome nucleosomes ortholog profound progressively reflected rtt106 shifted shifts spacing transcriptionally ways yta7 yta7delta	adjuvant clinicopathological computationally conclusionwe conjunction contexts datasets decade decisions dx incorporated indices introductiongenetic inverted marks methodwe nottingham oncotype prediction probabilistic ras resultsgenes seq signature signatures stratification stratified ubiquitous vary
Tagcloud (Intersection) ?