ATAD2 and MYC

Number of citations: 114 (PubMedID 29467282)
Data Source: BioGRID (affinity chromatography technology, proximity labelling technology, pull down)

		ATAD2	MYC
Name		ATPase family AAA domain containing 2	MYC proto-oncogene, bHLH transcription factor
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Extracellular Exosome	Chromatin Euchromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Nuclear Body Axon Protein-containing Complex Perinuclear Region Of Cytoplasm Myc-Max Complex RNA Polymerase II Transcription Repressor Complex
	Molecular Function	Nucleotide Binding Chromatin Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Core Promoter Sequence-specific DNA Binding Transcription Coregulator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein-containing Complex Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding SCF Ubiquitin Ligase Complex Binding
	Biological Process	Nucleosome Assembly Nucleosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis B Cell Apoptotic Process NK T Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of B Cell Apoptotic Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis DNA Damage Response Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Radiation Response To Xenobiotic Stimulus Regulation Of Gene Expression Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Myotube Differentiation Wnt Signaling Pathway RRNA Metabolic Process Protein Processing Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Protein-DNA Complex Disassembly Cellular Response To UV Cellular Response To Interferon-alpha Skeletal Muscle Cell Differentiation Middle Ear Morphogenesis Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Alkaloid Pigmentation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Skeletal System Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chromosome Organization Negative Regulation Of Cell Division Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Transcription Initiation By RNA Polymerase II ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of MiRNA Transcription Regulation Of Somatic Stem Cell Population Maintenance Positive Regulation Of Acinar Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Apoptotic Signaling Pathway
Pathways		TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Transcription of E2F targets under negative control by DREAM complex Signaling by ALK NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Regulation of CDH1 mRNA translation by microRNAs Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription
Drugs		None	Acetylsalicylic acid Dimethyl sulfoxide Doconexent Nadroparin
Diseases		None	Penile cancer Breast cancer Laryngeal cancer Oral cancer Multiple myeloma Kaposi's sarcoma Ovarian cancer Choriocarcinoma Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Burkitt lymphoma Small cell lung cancer Osteosarcoma Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		No GWAS studies recorded	Alcohol use disorder ( 30940813 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 23817571 ) Asthma ( 34103634 32296059 30929738 ) Asthma (childhood onset) ( 31036433 30929738 ) Bladder cancer ( 20972438 ) Breast cancer ( 29059683 23535729 ) Chronic lymphocytic leukemia ( 23770605 ) Colorectal cancer ( 24737748 25990418 26151821 23266556 ) Colorectal cancer or advanced adenoma ( 30510241 ) Diffuse large B cell lymphoma ( 25261932 ) Endometrial cancer ( 30093612 27135401 ) Endometrial cancer (endometrioid histology) ( 30093612 ) Endometrial endometrioid carcinoma ( 27135401 ) Glioblastoma ( 29743610 ) Glioma ( 29743610 ) Height ( 25429064 ) Multiple sclerosis ( 21833088 ) Non-glioblastoma glioma ( 29743610 ) Nonsyndromic cleft lip with cleft palate ( 28232668 ) Ovarian cancer ( 20852632 23535730 ) Pancreatic cancer ( 27579533 29422604 25086665 ) Prostate cancer ( 24753544 ) Prostate cancer (early onset) ( 24740154 ) Prostate-specific antigen levels ( 28139693 ) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693 ) Renal cell carcinoma ( 24220699 ) Serum alkaline phosphatase levels ( 33547301 ) Urinary bladder cancer ( 24861552 18794855 20348956 )
Interacting Genes		12 interacting genes: BAG4 BCAR3 CASP8 E2F1 E2F2 E2F3 E2F4 ESR1 H3-4 H4C14 MYC NCOA3	182 interacting genes: ACTL6A AKT1 APP ARAF ARNT ATAD2 ATG5 AURKA AXIN1 BCL2 BIN1 BRCA1 BRD3 CBLC CCAR2 CCNE1 CCNT1 CDC6 CDC73 CDCA7L CDK1 CDK6 CDK8 CDKN1B CDKN2A CDKN2B CDKN2C CEBPA CEBPB CEP57 CHD8 CHUK CIP2A CREBBP CSNK2A1 CSNK2A2 DACH1 DNMT3A EFNB1 ELF3 ELP3 EP300 EP400 EPHA2 ERBB2 FBXO32 FBXO8 FBXW7 FBXW8 FGFR4 FZR1 GCN1 GLIS1 GLIS2 GPX2 GRM1 GSK3A GSK3B GTF2F1 GTF2I HIF1A HNRNPD HSP90AA1 IKBKB ING4 KAT2A KAT2B KAT5 KDELR2 KDM1A KIDINS220 LATS2 LDOC1 MAP2K1 MAP2K5 MAPK1 MAPK14 MAPK3 MAPK7 MAPK8 MAX MDM2 MED1 MED16 MEN1 MET MLH1 MOK MXD1 MXI1 MYCBP MYCBP2 NDRG1 NEK11 NF2 NFIC NFYB NFYC NMI NONO NOTCH3 NUCB1 OTUB1 PAK2 PARP10 PCGF6 PDGFRA PFDN5 PIK3CA PLAU PLK1 PML PPP2CA PPP3R1 PRDX1 PSMC3 PTEN RAF1 RASSF1 RB1 RBL1 RELA RIOX2 SAP130 SENP2 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SOX3 SOX4 SP1 SPAG9 STK11 SUPT3H TADA2A TAF12 TAF1B TAF9 TBP TEAD2 TERT TFAP2A TFAP2B TIAM1 TONSL TP53 TP73 TRIB3 TRIM6 TRIM63 TRIP12 TRRAP TSC1 TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB UBE3B UBR5 USP1 USP2 USP36 USP37 USP45 USP7 VDR WT1 YAF2 YBX1 YY1 ZBTB17 ZNF281
Entrez ID		29028	4609
HPRD ID		10678	01818
Ensembl ID		ENSG00000156802	ENSG00000136997
Uniprot IDs		Q6PL18	P01106
PDB IDs		3DAI 4QSP 4QSQ 4QSR 4QSS 4QST 4QSU 4QSV 4QSW 4QSX 4QUT 4QUU 4TT2 4TT4 4TT6 4TTE 4TU4 4TU6 4TYL 4TZ2 4TZ8 5A5N 5A5O 5A5P 5A5Q 5A5R 5A81 5A82 5A83 5EPB 5F36 5F3A 5LJ0 5QXI 5QXJ 5QXK 5QXL 5QXM 5QXN 5QXO 5QXP 5QXQ 5QXR 5QXS 5QXT 5QXU 5QXV 5QXW 5QXX 5QXY 5QXZ 5QY0 5R4E 5R4F 5R4V 5R4W 5R4X 5R4Y 5R4Z 6CPS 6EPJ 6EPR 6EPS 6EPT 6EPU 6EPV 6EPW 6EPX 6HDN 6HDO 6HI3 6HI4 6HI5 6HI6 6HI7 6HI8 6HIA 6HIB 6HIC 6HID 6HIE 6S55 6S56 6S57 6YB4 7M98 7PPX 7PX5 7Q6T 7Q6U 7Q6V 7Q6W 7QU7 7QUK 7QUM 7QWO 7QX1 7QXT 7QYK 7QYL 7QZM 7QZY 7QZZ 7R00 7R05 7R0Y 7Z9H 7Z9I 7Z9J 7Z9N 7Z9O 7Z9S 7Z9U 8H3H 8JUW 8JUY 8JUZ 8RU5 8SDO 8SDQ	1A93 1EE4 1MV0 1NKP 2A93 2OR9 4Y7R 5I4Z 5I50 6C4U 6E16 6E24 6G6J 6G6K 6G6L 7T1Y 7T1Z 8J2Q 8OTS 8OTT 8Q1N 8WLG 8X8S 8X8V
GO Terms Enriched among Interactors		Protein Dimerization Activity Cis-regulatory Region Sequence-specific DNA Binding Transcription Regulator Complex DNA-binding Transcription Activator Activity RNA Polymerase II Transcription Regulator Complex Chromatin DNA-binding Transcription Factor Activity Lens Fiber Cell Apoptotic Process Negative Regulation Of Fat Cell Proliferation Rb-E2F Complex Protein-containing Complex Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Regulation Of Fibroblast Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Developmental Process Chromatin Remodeling Apoptotic Signaling Pathway Response To Estradiol Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Chromatin Organization Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Nucleoplasm Nucleobase-containing Compound Biosynthetic Process Sequence-specific DNA Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Protein-DNA Complex Assembly Cellular Response To Estradiol Stimulus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Apoptotic Process Transcription Coregulator Binding Regulation Of Myeloid Cell Differentiation Positive Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Epithelial Cell Apoptotic Process	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Nucleoplasm Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Population Proliferation Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Macromolecule Metabolic Process Regulation Of Apoptotic Process DNA-binding Transcription Factor Binding Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Cell Differentiation Chromatin Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Stability Protein Modification Process Regulation Of Protein Modification Process Chromatin Binding