NCALD and CLTC

Number of citations of the paper that reports this interaction (PMID 11964161)
15

Data Source:
HPRD (in vivo, in vitro)

		NCALD	CLTC
Gene Name		neurocalcin delta	clathrin, heavy chain (Hc)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle Extracellular Vesicular Exosome	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Actin Binding Calcium Ion Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Synaptic Transmission Vesicle-mediated Transport Calcium-mediated Signaling	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Coffee consumption ( 21876539) Cognitive performance ( 20125193)
Protein-Protein Interactions		8 interactors: ACTB C1QTNF2 CLTC DTX2 MEOX2 PNP TUBA4A TUBB	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		83988	1213
HPRD ID		09466	00350
Ensembl ID		ENSG00000104490	ENSG00000141367
Uniprot IDs		B2RB70 P61601	Q00610
PDB IDs			2XZG 4G55
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Inosine Catabolic Process NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Nicotinamide Riboside Catabolic Process Protein Polymerization Interleukin-2 Secretion Urate Biosynthetic Process G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Mitotic Cell Cycle Process Mitotic Cell Cycle Platelet Activation Somite Specification Cellular Component Assembly Establishment Of Localization In Cell Interleukin-2 Production Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Immune System Process Protein Complex Assembly Cell Cycle Process Protein Heterotrimerization Urate Metabolic Process Protein Folding Purine Ribonucleoside Catabolic Process Positive Regulation Of Glycogen Biosynthetic Process Cellular Localization Cellular Protein Complex Assembly Segment Specification Positive Regulation Of Fatty Acid Oxidation	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		8q22 antiepileptic autistic disability dysmorphic encompassed epilepsy epileptic girl intellectual iq kuechler lips neurocalcin overlapping proposita q22 recognizable refined ribonucleotide rrm2b seizure sentences smallest spoke telecanthus vermilion walked word	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		8q22 antiepileptic autistic disability dysmorphic encompassed epilepsy epileptic girl intellectual iq kuechler lips neurocalcin overlapping proposita q22 recognizable refined ribonucleotide rrm2b seizure sentences smallest spoke telecanthus vermilion walked word	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?