NCALD and PLAAT2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NCALD	PLAAT2
Description		neurocalcin delta	phospholipase A and acyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Clathrin Coat Of Trans-Golgi Network Vesicle	Cytoplasm Cytosol Membrane
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Tubulin Binding Clathrin Binding Alpha-tubulin Binding Metal Ion Binding	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity
	Biological Process	Regulation Of Systemic Arterial Blood Pressure Regulation Of Signal Transduction Vesicle-mediated Transport Calcium-mediated Signaling	Lipid Metabolic Process Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling N-acylphosphatidylethanolamine Metabolic Process
Pathways		Activation of Ca-permeable Kainate Receptor	Acyl chain remodelling of PE
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Cerebral amyloid angiopathy ( 25188341) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Coffee consumption ( 21876539) Cognitive performance ( 20125193) Coronary artery disease ( 33020668) Gait speed in old age ( 28077804) LDL peak particle diameter (total fat intake interaction) ( 26112879) Medication use (beta blocking agents) ( 31015401) Microalbuminuria ( 26631737) Perceived sweetness of sucrose ( 31005972) Red cell distribution width ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		33 interacting genes: ACTB ANOS1 APOL3 C19orf44 C1QTNF2 CLTC CREM DTX2 FGF6 FZD7 GOLGA7 GPX7 IGFBP6 KRT6A LCE2D LIF LITAF LY6G6D MEOX2 MICOS10-NBL1 MIEF2 MLLT10 MYDGF NBL1 PLAAT2 PNP SBSN SPRED1 SRGN TMEM14B TPSG1 TUBA4A TUBB	6 interacting genes: ASPH HPCAL1 NCALD UBAC1 UBQLN1 UBQLN2
Entrez ID		83988	54979
HPRD ID		09466	13670
Ensembl ID		ENSG00000104490	ENSG00000133328
Uniprot IDs		B2RB70 P61601	Q9NWW9
PDB IDs			4DPZ
Enriched GO Terms of Interacting Partners?		Extracellular Region Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Structural Constituent Of Cytoskeleton Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Maintenance Of Protein Location Extracellular Space Protein Binding Maintenance Of Location	Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Calcium-mediated Signaling Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Activation Of Store-operated Calcium Channel Activity Regulation Of Cell Communication Positive Regulation Of Protein Metabolic Process Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Protein Catabolic Process Regulation Of Calcium Ion Transport Clathrin Coat Of Trans-Golgi Network Vesicle Cortical Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagy Positive Regulation Of Calcium Ion Transport Into Cytosol Aggrephagy Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Receptor Internalization Regulation Of Metal Ion Transport Proteasome Binding Regulation Of Clathrin-dependent Endocytosis
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