FRMD8 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRMD8	PLEKHF2
Description		FERM domain containing 8	pleckstrin homology and FYVE domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Centriolar Satellite	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32271837 32514006) Urate levels ( 31578528)	Radiation response ( 20923822)
Interacting Genes		9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		83786	79666
HPRD ID		13326	15147
Ensembl ID		ENSG00000126391	ENSG00000175895
Uniprot IDs		A8K6L3 Q9BZ67	Q9H8W4
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Monoatomic Ion Transport Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Homeostasis Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Heart Rate By Hormone Ubiquitin Protein Ligase Binding T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of Calcium Ion Transmembrane Transport Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Heart Rate By Chemical Signal Inward Rectifier Potassium Channel Complex Antigen Receptor-mediated Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Homeostatic Process	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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