FRMD8 and GRAMD2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRMD8	GRAMD2B
Description		FERM domain containing 8	GRAM domain containing 2B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Centriolar Satellite	Cytoplasm Cytoplasmic Microtubule
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Tumor Necrosis Factor Production Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Alanine aminotransferase levels ( 33547301) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alanine transaminase) ( 33972514) Refractive error ( 32231278) Serum uric acid levels ( 32271837 32514006) Urate levels ( 31578528)	Tuberculosis ( 30713548) Vaginal microbiome composition (L. crispatus) ( 32723796)
Interacting Genes		9 interacting genes: APP FATE1 GRAMD2B IKBKG KCNH2 LIME1 PLEKHF2 ZNF446 ZNF474	11 interacting genes: ABO CD207 CDC37 FRMD8 GIMAP5 MORF4L2 NAPRT PAEP SEC22A TMEM43 VAMP5
Entrez ID		83786	65983
HPRD ID		13326	11402
Ensembl ID		ENSG00000126391	ENSG00000155324
Uniprot IDs		A8K6L3 Q9BZ67	Q96HH9
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Monoatomic Ion Transport Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Monoatomic Cation Homeostasis Regulation Of Metal Ion Transport Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Identical Protein Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Heart Rate By Hormone Ubiquitin Protein Ligase Binding T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling B Cell Receptor Complex Negative Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of Calcium Ion Transmembrane Transport Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Heart Rate By Chemical Signal Inward Rectifier Potassium Channel Complex Antigen Receptor-mediated Signaling Pathway Regulation Of Spontaneous Synaptic Transmission Homeostatic Process	Glycoprotein-fucosylgalactoside Alpha-N-acetylgalactosaminyltransferase Activity Fucosylgalactoside 3-alpha-galactosyltransferase Activity Negative Regulation Of Sperm Capacitation Nicotinate Phosphoribosyltransferase Activity
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