RPS6KA5 and EIF4EBP1

Number of citations of the paper that reports this interaction (PMID 11777913)
11

Data Source:
HPRD (in vitro)

		RPS6KA5	EIF4EBP1
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 5	eukaryotic translation initiation factor 4E binding protein 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Cytoplasm Cytosol Protein Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	Negative Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Histone Acetylation Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle IRES-dependent Translational Initiation Response To Ischemia Translation Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Lung Development Negative Regulation Of Protein Complex Assembly TOR Signaling Cellular Protein Metabolic Process Response To Ethanol Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Translational Initiation
Pathways		CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	IRS-mediated signalling mTOR signalling mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade IRS-related events triggered by IGF1R Release of eIF4E Eukaryotic Translation Initiation PKB-mediated events Cap-dependent Translation Initiation PI3K Cascade Signaling by Insulin receptor Insulin receptor signalling cascade Translation IRS-related events Release of eIF4E mTORC1-mediated signalling IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		59 interactors: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B DDAH2 DNAJC11 EIF4E EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 HIST1H1B HIST1H3E HIST2H2BE HIST2H3C HIST2H4A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HMGN1 HSPB1 HSPB2 IL17RB ITSN1 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZAK ZNF775	32 interactors: AKT1 ATM BUB1 CHTF8 CSNK2A1 CSNK2A2 EIF4E EIF4E2 GSK3B IRAK4 LATS1 LRRK2 MAPK1 MAPK14 MAPKAP1 MAPKAPK5 MLST8 MTOR MVD PPP2CA PPP2R4 PRKCA PRKDC REL RHEBL1 RICTOR RORC RPS6KA5 RPS6KB1 RPTOR STK3 TCF4
Entrez ID		9252	1978
HPRD ID		06789	03746
Ensembl ID		ENSG00000100784	ENSG00000187840
Uniprot IDs		B7Z2Y5 O75582 Q9UG98	Q13541
PDB IDs		1VZO 3KN5 3KN6	1WKW 2JGB 2JGC 2V8W 2V8X 2V8Y 3HXG 3HXI 3M93 3M94 3U7X
Enriched GO Terms of Interacting Partners?		Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Response To Abiotic Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Stress Neurotrophin Signaling Pathway Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cell Differentiation Innate Immune Response Immune Response Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor System Development Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Anatomical Structure Development Response To Hormone Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Multicellular Organismal Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Immune System Process Chromatin Organization Chromosome Organization Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Stress-activated MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Peptidyl-serine Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Phosphorylation Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Cell Cycle Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Signaling Cell Cycle Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Cellular Protein Modification Process Regulation Of Protein Phosphorylation Cell Communication Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Response To Heat Regulation Of Cellular Response To Heat Cellular Response To Fibroblast Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Protein Metabolic Process Response To Growth Factor Negative Regulation Of Cellular Protein Metabolic Process Innate Immune Response Cell Death
Tagcloud ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?