RPS6KA5 and MAPK11

Number of citations of the paper that reports this interaction (PMID 9687510)
205

Data Source:
HPRD (in vitro)

		RPS6KA5	MAPK11
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 5	mitogen-activated protein kinase 11
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Histone Acetylation Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Protein Phosphorylation Response To Stress Organelle Organization Mitochondrion Organization Signal Transduction Ras Protein Signal Transduction Gene Expression Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Muscle Cell Differentiation Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade
Pathways		CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Cellular Senescence Toll Like Receptor TLR1:TLR2 Cascade Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway p38MAPK events MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets activated TAK1 mediates p38 MAPK activation Regulation of mRNA stability by proteins that bind AU-rich elements CDO in myogenesis TRIF-mediated TLR3/TLR4 signaling Toll Like Receptor 2 (TLR2) Cascade Activation of PPARGC1A (PGC-1alpha) by phosphorylation Myogenesis Signaling by VEGF Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Signalling to RAS Signalling to ERKs Organelle biogenesis and maintenance Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway Activated TLR4 signalling Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Mitochondrial biogenesis Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade DSCAM interactions Oxidative Stress Induced Senescence KSRP destabilizes mRNA Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ERK/MAPK targets MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)
Protein-Protein Interactions		59 interactors: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B DDAH2 DNAJC11 EIF4E EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 HIST1H1B HIST1H3E HIST2H2BE HIST2H3C HIST2H4A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HMGN1 HSPB1 HSPB2 IL17RB ITSN1 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZAK ZNF775	27 interactors: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK3 MAPKAPK5 MAPT MBP NOXA1 PML POLR3D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		9252	5600
HPRD ID		06789	04208
Ensembl ID		ENSG00000100784	ENSG00000185386
Uniprot IDs		B7Z2Y5 O75582 Q9UG98	L7RT27 Q15759
PDB IDs		1VZO 3KN5 3KN6	3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?		Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Response To Abiotic Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Stress Neurotrophin Signaling Pathway Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cell Differentiation Innate Immune Response Immune Response Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor System Development Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Anatomical Structure Development Response To Hormone Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Multicellular Organismal Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Immune System Process Chromatin Organization Chromosome Organization Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Stress-activated MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway	Regulation Of Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Toll-like Receptor 4 Signaling Pathway Innate Immune Response Response To Stress Signal Transduction By Phosphorylation Regulation Of Immune Response Cellular Response To Stress Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Response To Organic Substance Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Immune Response Phosphorylation Signaling Cellular Response To Organic Substance Regulation Of Signal Transduction Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Signaling Immune System Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Lipid Response To Growth Factor Intracellular Signal Transduction Regulation Of Growth
Tagcloud ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought
Tagcloud (Difference) ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	antagonists antitumor bbc3 bcl2 ca cacna1g caco2 cdkn1a channel channels express hct116 knockdown mapkalpha occupancy p21cip1 p38 p53 p53wt promoted puma rationale rnai sb203580 ser392 stably thought
Tagcloud (Intersection) ?		mapk14