RPS6KA5 and MDFIC

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RPS6KA5	MDFIC
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 5	MyoD family inhibitor domain containing
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding Transcription Factor Binding Cyclin Binding Tat Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Histone Acetylation Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Transcription, DNA-templated Activation Of JUN Kinase Activity Viral Process Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways		CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Obesity ( 23818313)
Protein-Protein Interactions		59 interactors: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B DDAH2 DNAJC11 EIF4E EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 HIST1H1B HIST1H3E HIST2H2BE HIST2H3C HIST2H4A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HMGN1 HSPB1 HSPB2 IL17RB ITSN1 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZAK ZNF775	4 interactors: CCNT1 CDK9 RPS6KA5 SOCS4
Entrez ID		9252	29969
HPRD ID		06789	17103
Ensembl ID		ENSG00000100784	ENSG00000135272
Uniprot IDs		B7Z2Y5 O75582 Q9UG98	Q9P1T7
PDB IDs		1VZO 3KN5 3KN6
Enriched GO Terms of Interacting Partners?		Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Response To Abiotic Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Stress Neurotrophin Signaling Pathway Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cell Differentiation Innate Immune Response Immune Response Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor System Development Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Anatomical Structure Development Response To Hormone Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Multicellular Organismal Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Immune System Process Chromatin Organization Chromosome Organization Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Stress-activated MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway	Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Viral Transcription Positive Regulation Of Viral Process Cellular Response To Growth Factor Stimulus Cellular Response To Cytokine Stimulus Response To Growth Factor DNA-templated Transcription, Elongation Regulation Of Protein Metabolic Process Response To Cytokine Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Histone H2A-S1 Phosphorylation Replication Fork Arrest Regulation Of Histone Modification Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Viral Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Phosphorylation Response To Transforming Growth Factor Beta Regulation Of Chromosome Organization Positive Regulation Of Metabolic Process DNA-templated Transcription, Initiation Histone H3-S10 Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Histone Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone H3-S28 Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Phosphorylation Regulation Of Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Cellular Ketone Metabolic Process
Tagcloud ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify
Tagcloud (Difference) ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify
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