RPS6KA5 and CEBPB

Number of citations of the paper that reports this interaction (PMID 10635333)
42

Data Source:
HPRD (in vivo)

		RPS6KA5	CEBPB
Gene Name		ribosomal protein S6 kinase, 90kDa, polypeptide 5	CCAAT/enhancer binding protein (C/EBP), beta
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Condensed Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Cytokine Production Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Protein Phosphorylation Inflammatory Response Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Histone Phosphorylation Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Histone Acetylation Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Histone H3-S10 Phosphorylation Histone H3-S28 Phosphorylation Histone H2A-S1 Phosphorylation Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Embryonic Placenta Development Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Acute-phase Response Inflammatory Response Immune Response Neuron Differentiation Response To Lipopolysaccharide Mammary Gland Epithelial Cell Proliferation Response To Endoplasmic Reticulum Stress Negative Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Brown Fat Cell Differentiation Mammary Gland Epithelial Cell Differentiation Regulation Of Transcription Involved In Cell Fate Commitment Cellular Response To Amino Acid Stimulus
Pathways		CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation L1CAM interactions Recycling pathway of L1 Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Toll Like Receptor 9 (TLR9) Cascade ERK/MAPK targets Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)	Transcriptional regulation of white adipocyte differentiation Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS		Bone mineral density ( 22504420)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		59 interactors: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CSNK2B DDAH2 DNAJC11 EIF4E EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 HIST1H1B HIST1H3E HIST2H2BE HIST2H3C HIST2H4A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 HMGN1 HSPB1 HSPB2 IL17RB ITSN1 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZAK ZNF775	54 interactors: AR ATF2 ATF4 CAMK2A CCL3 CEBPA CEBPD CEBPG CREB1 CREBBP DDIT3 EGFR EGR1 ELK1 EP300 ESR1 FOXO1 HMGA1 HMGB1 HNRNPK HOMER3 HSF1 KAT2A KAT2B MAPK1 MAPK3 MED23 MYB MYC NCOR2 NFKB1 NOLC1 NR3C1 PTGES2 RARB RB1 RELA RPS6KA1 RPS6KA5 RUNX1 RUNX2 SMAD3 SMAD4 SMARCA4 SMARCB1 SMARCC1 SP1 SPI1 SPIB SRF STAT5A STAT6 TAF9 TRIM28
Entrez ID		9252	1051
HPRD ID		06789	01801
Ensembl ID		ENSG00000100784	ENSG00000172216
Uniprot IDs		B7Z2Y5 O75582 Q9UG98	P17676
PDB IDs		1VZO 3KN5 3KN6	1GTW 1GU4 1GU5 1H88 1H89 1H8A 1HJB 1IO4 2E42 2E43
Enriched GO Terms of Interacting Partners?		Response To Stress Positive Regulation Of Cellular Metabolic Process Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Defense Response Enzyme Linked Receptor Protein Signaling Pathway Response To Abiotic Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Stress Neurotrophin Signaling Pathway Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cell Differentiation Innate Immune Response Immune Response Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor System Development Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Anatomical Structure Development Response To Hormone Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Multicellular Organismal Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Immune System Process Chromatin Organization Chromosome Organization Generation Of Neurons TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Immune Response-regulating Signaling Pathway Stress-activated MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Response To Organic Substance Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Gene Expression DNA-templated Transcription, Initiation Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Immune System Process Cellular Metabolic Process System Development Developmental Process Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Anatomical Structure Development Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus
Tagcloud ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Difference) ?		27a 5p arrays bioinformatics cbl changed creb creb1 directive erk2 escc esophageal folds grb2 mapk1 mapk14 microrna mir mirna mirnas ngfr options prediction pt1n0 sos1 sprouty spry2 taqman verify	activates anticancer atf4 attenuated autophagy chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3
Tagcloud (Intersection) ?