RPS6KA5 and PDLIM1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA5	PDLIM1
Description		ribosomal protein S6 kinase A5	PDZ and LIM domain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Stress Fiber Transcription Regulator Complex Cytoplasm Cytoskeleton Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Fibroblast Migration Maintenance Of Cell Polarity Actin Cytoskeleton Organization Establishment Or Maintenance Of Actin Cytoskeleton Polarity Stress Fiber Assembly Positive Regulation Of DNA-templated Transcription Muscle Structure Development Cell-cell Adhesion
Pathways		ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hemoglobin ( 32888494) Mean platelet volume ( 27863252 32888494) Suicide risk ( 21041247) White blood cell count ( 32888494)
Interacting Genes		60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775	16 interacting genes: ACTN1 ACTN2 ACTN4 AGK GABARAPL2 GFAP MAP1LC3C MAPK6 PGS1 PITX2 PTGER4 RLIM RPS6KA5 STK35 SUPT4H1 VIM
Entrez ID		9252	9124
HPRD ID		06789	09326
Ensembl ID		ENSG00000100784	ENSG00000107438
Uniprot IDs		O75582	O00151 V9HW92
PDB IDs		1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8	1X62 2PKT
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction	Pseudopodium Muscle Cell Development Integrin Binding Platelet Alpha Granule Lumen Postsynaptic Actin Cytoskeleton Cortical Actin Cytoskeleton Bergmann Glial Cell Differentiation Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Cell Development Astrocyte Development Z Disc Transmembrane Transporter Binding Focal Adhesion Assembly Astrocyte Differentiation Organelle Organization Actin Filament Binding Positive Regulation Of Ion Transmembrane Transporter Activity Focal Adhesion Cell Junction Positive Regulation Of Transporter Activity Positive Regulation Of Macromolecule Biosynthetic Process Cell-substrate Junction Organization Cell-substrate Junction Assembly Cardiac Cell Development Actin Filament Uncapping Cardiac Muscle Cell Development Intermediate Filament Cytoskeleton Superior Vena Cava Morphogenesis Subthalamic Nucleus Development Negative Regulation Of Eosinophil Extravasation Histone H2AS1 Kinase Activity CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Activity Autophagosome Maturation Acylglycerol Kinase Activity Autophagosome Membrane Sarcomere Mitophagy Positive Regulation Of Biosynthetic Process Cytoskeleton Organization Cytoskeleton Cytoskeletal Protein Binding Structural Constituent Of Postsynapse Titin Z Domain Binding Glial Cell Development Left Lung Morphogenesis Prolactin Secreting Cell Differentiation Cell Proliferation Involved In Outflow Tract Morphogenesis Pulmonary Vein Morphogenesis Septin Cytoskeleton
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