CASP4 and MYH9

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CASP4	MYH9
Gene Name		caspase 4, apoptosis-related cysteine peptidase	myosin, heavy chain 9, non-muscle
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Stress Fiber Ruffle Immunological Synapse Uropod Nucleus Cytoplasm Spindle Actomyosin Contractile Ring Cytosol Plasma Membrane Cell-cell Adherens Junction COP9 Signalosome Integrin Complex Actin Cytoskeleton Membrane Myosin II Complex Cortical Cytoskeleton Cell Leading Edge Neuromuscular Junction Cleavage Furrow Actomyosin Protein Complex Extracellular Vesicular Exosome Myosin II Filament
	Molecular Function	Cysteine-type Endopeptidase Activity	Microfilament Motor Activity Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Protein Homodimerization Activity Protein Anchor ADP Binding Poly(A) RNA Binding Actin Filament Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Regulation Of Inflammatory Response Execution Phase Of Apoptosis	Meiotic Spindle Organization Cytokinesis Angiogenesis In Utero Embryonic Development Establishment Of T Cell Polarity Membrane Protein Ectodomain Proteolysis Integrin-mediated Signaling Pathway Axon Guidance Myoblast Fusion Regulation Of Cell Shape Protein Transport Actin Filament-based Movement Platelet Formation Monocyte Differentiation Actomyosin Structure Organization Actin Cytoskeleton Reorganization Uropod Organization Termination Of G-protein Coupled Receptor Signaling Pathway Blood Vessel Endothelial Cell Migration Ephrin Receptor Signaling Pathway Leukocyte Migration Establishment Of Meiotic Spindle Localization Platelet Aggregation
Pathways		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System	EPHA-mediated growth cone collapse Axon guidance Semaphorin interactions EPH-Ephrin signaling Sema4D in semaphorin signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Sema4D induced cell migration and growth-cone collapse Innate Immune System
Drugs
Diseases
GWAS			End-stage renal disease (non-diabetic) ( 20532800) Glomerulosclerosis ( 20668430) Optic disc size (rim) ( 20395239)
Protein-Protein Interactions		17 interactors: APAF1 APP CASP1 CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	22 interactors: ASCC2 CASP4 CBL CD163 CSNK2A1 CXCR4 GRB2 GRIN1 MEN1 MYBPC3 MYH10 MYL9 MYOM1 MYOM2 OVGP1 PPP2CA PTPN6 RAC1 S100A4 TTN TUFM YWHAZ
Entrez ID		837	4627
HPRD ID		04047	01177
Ensembl ID		ENSG00000196954	ENSG00000100345
Uniprot IDs		P49662	P35579
PDB IDs			2LNK 3ZWH 4ETO
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Proteolysis Immune System Process Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Zymogen Activation Protein Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Neuron Apoptotic Process Apoptotic Signaling Pathway Neuron Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cell Activation Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Single Organismal Cell-cell Adhesion Leukocyte Aggregation Defense Response Positive Regulation Of Apoptotic Process Leukocyte Cell-cell Adhesion Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cytokine Production Homotypic Cell-cell Adhesion	Cell Morphogenesis Involved In Differentiation Cell Development Platelet Activation Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Locomotion Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Apoptotic Process Muscle Contraction Cell Activation Blood Coagulation Programmed Cell Death Hemostasis Ephrin Receptor Signaling Pathway Response To Wounding Cell Death Death Muscle System Process Neuron Projection Development Cell Projection Morphogenesis Myosin Filament Assembly Cell Part Morphogenesis Regulation Of Body Fluid Levels Cell Differentiation Neuron Development Regulation Of Cellular Component Organization Actin Filament-based Movement Regulation Of Signaling Cell Surface Receptor Signaling Pathway Endomembrane System Organization Neuron Differentiation T Cell Costimulation Myofibril Assembly Leukocyte Migration Brain Development Cell Projection Organization Regulation Of Kinase Activity Head Development Regulation Of Signal Transduction Anatomical Structure Development
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic serves subfamily verified
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage sy5y	abundance acetylation attempt capability cognate consolidate coordinating cytoplasmic deacetylase deacetylation diversity dnaj dnaja1 elucidated hdac6 homolog hsc70 knockout modulates monitor myosin negatively notion participates predominantly proteomic subfamily verified
Tagcloud (Intersection) ?		serves