CASP4 and IL1B

Number of citations of the paper that reports this interaction (PubMedID 7797510)
0

Data Source:
HPRD (in vitro)

		CASP4	IL1B
Description		caspase 4	interleukin 1 beta
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex	Extracellular Region Extracellular Space Cytoplasm Lysosome Cytosol Secretory Granule Vesicle
	Molecular Function	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding Receptor Ligand Activity
	Biological Process	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Fever Generation Positive Regulation Of Cytokine Production Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Immune Response Signal Transduction JNK Cascade Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Carbohydrate Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of D-glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Ectopic Germ Cell Programmed Cell Death Positive Regulation Of T Cell Proliferation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of DNA-templated Transcription Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Defense Response To Gram-positive Bacterium Leukocyte Migration Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Interleukin-17 Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Regulation Of Secretion By Cell Negative Regulation Of Gap Junction Assembly Positive Regulation Of Tight Junction Disassembly Positive Regulation Of T-helper 1 Cell Cytokine Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage	Interleukin-1 processing Pyroptosis CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage
Drugs		Incadronic acid	Donepezil Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Foreskin keratinocyte (neonatal) Binimetinib Gevokizumab Dilmapimod
Diseases
GWAS		Major depressive disorder ( 29317602)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)
Interacting Genes		16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	17 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FBXL2 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 NEDD4 PRTN3 SP1
Entrez ID		837	3553
HPRD ID		04047	00985
Ensembl ID		ENSG00000196954	ENSG00000125538
Uniprot IDs		P49662	P01584
PDB IDs		6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB	1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 5R7W 5R85 5R86 5R87 5R88 5R89 5R8A 5R8B 5R8C 5R8D 5R8E 5R8F 5R8G 5R8H 5R8I 5R8J 5R8K 5R8L 5R8M 5R8N 5R8O 5R8P 5R8Q 6I1B 6Y8I 6Y8M 7CHY 7CHZ 7I1B 7Z4T 8C3U 8RYK 8RYS 8RZB 9ILB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process	Enzyme Binding Regulation Of Inflammatory Response Regulation Of Defense Response Cellular Response To Oxygen-containing Compound Response To Amyloid-beta Cytokine Precursor Processing Interleukin-1-mediated Signaling Pathway Interleukin-1 Receptor Activity Immune System Process Interleukin-1 Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Proteolysis Cytokine-mediated Signaling Pathway Regulation Of Cell Communication Cellular Response To Amyloid-beta Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Response To Stress Protein Processing Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Multicellular Organismal Process Endopeptidase Activity Membrane Raft Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ephrin Receptor Binding Protein Metabolic Process Peptidase Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Neuron Apoptotic Process Regulation Of Interleukin-1 Production Positive Regulation Of Intracellular Signal Transduction Collagen Catabolic Process Growth Factor Receptor Binding Signaling Receptor Ligand Precursor Processing Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extracellular Region Protein Maturation NLRP1 Inflammasome Complex Extracellular Matrix Disassembly Serine-type Endopeptidase Activity Glutamate Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Metal Ion Transport Heparan Sulfate Binding
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