CASP4 and IL37

Number of citations of the paper that reports this interaction (PMID 12096920)
29

Data Source:
BioGRID (enzymatic study)

		CASP4	IL37
Gene Name		caspase 4, apoptosis-related cysteine peptidase	interleukin 37
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity	Cytokine Activity Interleukin-1 Receptor Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Regulation Of Inflammatory Response Execution Phase Of Apoptosis	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway
Pathways		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APAF1 APP CASP1 CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	5 interactors: CASP1 CASP4 IL18BP IL18R1 SMAD3
Entrez ID		837	27178
HPRD ID		04047	05695
Ensembl ID		ENSG00000196954	ENSG00000125571
Uniprot IDs		P49662	Q9NZH6
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Proteolysis Immune System Process Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Zymogen Activation Protein Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Neuron Apoptotic Process Apoptotic Signaling Pathway Neuron Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cell Activation Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Single Organismal Cell-cell Adhesion Leukocyte Aggregation Defense Response Positive Regulation Of Apoptotic Process Leukocyte Cell-cell Adhesion Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cytokine Production Homotypic Cell-cell Adhesion	Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production T-helper 1 Type Immune Response Regulation Of Inflammatory Response Positive Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Regulation Of Interleukin-1 Beta Production Immune Response Execution Phase Of Apoptosis Regulation Of Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Transcription Factor Import Into Nucleus Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Protein Transport Zymogen Activation Cellular Response To Organic Substance Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Transforming Growth Factor Beta3 Production Interleukin-18-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Response To Other Organism Positive Regulation Of Transport Positive Regulation Of Endopeptidase Activity Response To Biotic Stimulus Immune System Process Regulation Of Protein Localization Positive Regulation Of Peptidase Activity Cellular Response To Interleukin-18 Mitochondrial Depolarization Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organic Substance Evasion Or Tolerance Of Host Defenses By Virus Response To Interleukin-18 Positive Regulation Of Interleukin-1 Alpha Secretion Apoptotic Process Regulation Of Protein Localization To Nucleus Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Cellular Localization Regulation Of Nucleocytoplasmic Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y
Tagcloud (Intersection) ?