CASP4 and NOD1

Number of citations of the paper that reports this interaction (PMID 10329646)
113

Data Source:
HPRD (in vivo)

		CASP4	NOD1
Gene Name		caspase 4, apoptosis-related cysteine peptidase	nucleotide-binding oligomerization domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding CARD Domain Binding
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Regulation Of Inflammatory Response Execution Phase Of Apoptosis	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Oligomerization Stress-activated MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Pathways		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 signaling TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APAF1 APP CASP1 CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	12 interactors: CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		837	10392
HPRD ID		04047	05815
Ensembl ID		ENSG00000196954	ENSG00000106100
Uniprot IDs		P49662	Q9Y239
PDB IDs			2B1W 2DBD 2NSN 2NZ7 4E9M
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Proteolysis Immune System Process Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Zymogen Activation Protein Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Neuron Apoptotic Process Apoptotic Signaling Pathway Neuron Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cell Activation Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Single Organismal Cell-cell Adhesion Leukocyte Aggregation Defense Response Positive Regulation Of Apoptotic Process Leukocyte Cell-cell Adhesion Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cytokine Production Homotypic Cell-cell Adhesion	Regulation Of Apoptotic Process Apoptotic Process Regulation Of Cell Death Programmed Cell Death Cell Death Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Intracellular Receptor Signaling Pathway Execution Phase Of Apoptosis Protein Processing Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Response To Bacterium Regulation Of Catalytic Activity Cellular Response To Mechanical Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Proteolysis Signal Transduction Response To Lipopolysaccharide Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Cobalt Ion Response To Other Organism Response To Molecule Of Bacterial Origin Apoptotic Signaling Pathway Response To Biotic Stimulus Signaling Cell Communication Innate Immune Response Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Secretion Response To Organic Cyclic Compound Proteolysis Positive Regulation Of Interleukin-1 Secretion
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric oligomerization p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomers parp phenolic ribose rosemary sage serves sy5y	bacterium boosted causative challenge chicken clostridium commercially consequently dosage enteritis gram initiated inos intense intestinal necrotic nitric p65 pathogen peptidoglycan perfringens pgn stimulators synthase toll toxin virulence wall
Tagcloud (Intersection) ?		oligomerization