CASP4 and CASP14

Number of citations of the paper that reports this interaction (PMID 9792675)
11

Data Source:
HPRD (in vivo)

		CASP4	CASP14
Gene Name		caspase 4, apoptosis-related cysteine peptidase	caspase 14, apoptosis-related cysteine peptidase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Nucleus Cytoplasm Keratin Filament Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity	Cysteine-type Endopeptidase Activity
	Biological Process	Proteolysis Apoptotic Process Regulation Of Apoptotic Process Regulation Of Inflammatory Response Execution Phase Of Apoptosis	Proteolysis Epidermis Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Keratinization Cornification Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: APAF1 APP CASP1 CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	8 interactors: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 MEOX2 UCHL5
Entrez ID		837	23581
HPRD ID		04047	05788
Ensembl ID		ENSG00000196954	ENSG00000105141
Uniprot IDs		P49662	B2CIS9 P31944
PDB IDs
Enriched GO Terms of Interacting Partners?		Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Proteolysis Immune System Process Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Response To Stress Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Activation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Zymogen Activation Protein Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Neuron Apoptotic Process Apoptotic Signaling Pathway Neuron Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cell Activation Regulation Of Cell Death Cellular Response To Stimulus Positive Regulation Of Cellular Protein Metabolic Process Response To Stimulus Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Signaling Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Cell Communication Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Single Organismal Cell-cell Adhesion Leukocyte Aggregation Defense Response Positive Regulation Of Apoptotic Process Leukocyte Cell-cell Adhesion Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cytokine Production Homotypic Cell-cell Adhesion	Execution Phase Of Apoptosis Proteolysis Cell Death Death Cellular Response To Mechanical Stimulus Regulation Of Endopeptidase Activity Apoptotic Process Regulation Of Peptidase Activity Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Proteolysis Regulation Of Apoptotic Process Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Regulation Of Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Apoptotic Signaling Pathway Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Signal Transduction Extrinsic Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Mitochondrial Depolarization Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Death Regulation Of Signal Transduction TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Peptidase Activity Regulation Of Signaling Luteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Pyroptosis Somite Specification Intracellular Receptor Signaling Pathway Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organic Substance Response To Stress
Tagcloud ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp8 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	abc bcl2af1 bcl2l10 biology casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Difference) ?		10mum abeta42 abeta43 aif carnosic cascades casp3 casp9 casps concurrently diterpene herbs ingestion initiator labiate monomer neurotoxicity neurotrophic oligomerization oligomers parp phenolic ribose rosemary sage serves sy5y	abc bcl2af1 bcl2l10 biology cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tnfrsf25 tnfsf8 tunel valuable
Tagcloud (Intersection) ?		casp8