CASP4 and CASP14

Number of citations of the paper that reports this interaction (PubMedID 9792675)
0

Data Source:
HPRD (in vivo)

		CASP4	CASP14
Description		caspase 4	caspase 14
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Protein-containing Complex Canonical Inflammasome Complex NLRP1 Inflammasome Complex Non-canonical Inflammasome Complex	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament
	Molecular Function	Lipopolysaccharide Binding Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Lipid Binding Hydrolase Activity CARD Domain Binding	Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Immune System Process Proteolysis Apoptotic Process Inflammatory Response Protein Secretion Programmed Cell Death Protein Autoprocessing Interleukin-18-mediated Signaling Pathway Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process NLRP3 Inflammasome Complex Assembly Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Protein Maturation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response Intrinsic Apoptotic Signaling Pathway Pyroptotic Cell Death Non-canonical Inflammasome Complex Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta Positive Regulation Of Interleukin-18-mediated Signaling Pathway	Proteolysis Epidermis Development Cell Differentiation Keratinization Positive Regulation Of Neuron Apoptotic Process Cornification
Pathways		NOD1/2 Signaling Pathway Pyroptosis CASP4 inflammasome assembly Microbial factors inhibit CASP4 activity CASP4-mediated substrate cleavage	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs		Incadronic acid
Diseases
GWAS		Major depressive disorder ( 29317602)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5
Entrez ID		837	23581
HPRD ID		04047	05788
Ensembl ID		ENSG00000196954	ENSG00000105141
Uniprot IDs		P49662	B2CIS9 P31944
PDB IDs		6KMZ 6NRY 7WR0 7WR1 7WR4 7WR5 7WR6 8J6K 8SPB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Defense Response Positive Regulation Of Neuron Apoptotic Process Regulation Of Cytokine Production Cell Death Programmed Cell Death Regulation Of Inflammatory Response Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Immune System Process Regulation Of Programmed Cell Death Regulation Of Interleukin-6 Production Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Astrocyte Activation Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Regulation Of Immune Response Execution Phase Of Apoptosis Regulation Of Interleukin-1 Beta Production Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Defense Response Regulation Of Interleukin-1 Production Defense Response To Gram-positive Bacterium Astrocyte Activation Involved In Immune Response Death Effector Domain Binding Regulation Of Immune System Process Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Cysteine-type Peptidase Activity Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Response To Lipopolysaccharide Inflammatory Response Apoptotic Signaling Pathway Response To Anesthetic Response To Molecule Of Bacterial Origin Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Multicellular Organismal Process Death-inducing Signaling Complex Natural Killer Cell Activation Positive Regulation Of T-helper 1 Cell Cytokine Production Cell Activation Positive Regulation Of Immune System Process	Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Peptidase Activity Positive Regulation Of Neuron Apoptotic Process Hydrolase Activity Proteolysis Protein Maturation Execution Phase Of Apoptosis Pyroptotic Inflammatory Response Protein Processing Death Effector Domain Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication NLRP1 Inflammasome Complex Positive Regulation Of Signaling Ripoptosome CD95 Death-inducing Signaling Complex Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Self Proteolysis Canonical Inflammasome Complex Interleukin-18-mediated Signaling Pathway CARD Domain Binding Pyroptotic Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Execution Phase Of Apoptosis Protein Autoprocessing Positive Regulation Of Inflammatory Response Regulation Of Cytokine-mediated Signaling Pathway Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Mechanical Stimulus Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Macrophage Differentiation Cytoplasm Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein-containing Complex Regulation Of Programmed Cell Death Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction
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