USP11 and MBD3

Number of citations of the paper that reports this interaction (PubMedID 31504778)
102

Data Source:
BioGRID (affinity chromatography technology, pull down)

		USP11	MBD3
Description		ubiquitin specific peptidase 11	methyl-CpG binding domain protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Proteolysis Protein Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Ventricular Cardiac Muscle Tissue Development Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Tissue Development Response To Nutrient Levels Response To Estradiol Epigenetic Regulation Of Gene Expression Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Response To Bisphenol A Regulation Of Stem Cell Differentiation
Pathways			HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS
Interacting Genes		26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC	73 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655
Entrez ID		8237	53615
HPRD ID		02081	04653
Ensembl ID		ENSG00000102226	ENSG00000071655
Uniprot IDs		G5E9A6	O95983
PDB IDs			2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound	NuRD Complex Chromatin Remodeling Regulation Of Cell Fate Specification Chromatin Organization Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Complex Regulation Of Cell Fate Commitment Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Nucleosomal DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Stem Cell Differentiation Sin3-type Complex Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Protein Binding Chromosome Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Chromosome, Telomeric Region Positive Regulation Of Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Membrane Curvature Sensor Activity Negative Regulation Of Protein Acetylation Epigenetic Regulation Of Gene Expression Somite Specification
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