USP11 and DECR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP11	DECR2
Description		ubiquitin specific peptidase 11	2,4-dienoyl-CoA reductase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Peroxisome Peroxisomal Membrane Cytosol
	Molecular Function	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Protein Binding 2,4-dienoyl-CoA Reductase (NADPH) Activity Oxidoreductase Activity Trans-2-enoyl-CoA Reductase (NADPH) Activity Protein-containing Complex Binding GTPase Binding
	Biological Process	Proteolysis Protein Deubiquitination	Lipid Metabolic Process Fatty Acid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase
Pathways			Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS			Body mass index ( 26426971) Hodgkin's lymphoma ( 34216518) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC	11 interacting genes: APP C14orf119 EP300 NEDD4L OSGIN1 PEX5 TRIM55 TRIM63 UBC USP11 VPS26C
Entrez ID		8237	26063
HPRD ID		02081	16789
Ensembl ID		ENSG00000102226	ENSG00000242612
Uniprot IDs		G5E9A6	Q9NUI1
PDB IDs			4FC6 4FC7
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound	Regulation Of Glycolytic Process Post-translational Protein Modification Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Growth Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Peptidyl-lysine Propionylation Swimming Canonical NF-kappaB Signal Transduction Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Receptor Metabolic Process Protein Monoubiquitination Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Myeloid Cell Development Regulation Of Multicellular Organism Growth Acetylcholine Receptor Activator Activity Response To Interleukin-1 Regulation Of Developmental Growth Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Ubiquitin Protein Ligase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation PTB Domain Binding Collateral Sprouting In Absence Of Injury
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