USP11 and HELLS

Number of citations of the paper that reports this interaction (PubMedID 37414755)
55

Data Source:
BioGRID (enzymatic study, pull down)

		USP11	HELLS
Description		ubiquitin specific peptidase 11	helicase, lymphoid specific
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin Site Of Double-strand Break
	Molecular Function	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity	Nucleotide Binding Chromatin Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity Chromatin-protein Adaptor Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	Proteolysis Protein Deubiquitination	Double-strand Break Repair Via Homologous Recombination Urogenital System Development Kidney Development Double-strand Break Repair Chromatin Remodeling DNA Methylation-dependent Constitutive Heterochromatin Formation Apoptotic Process Heterochromatin Formation Pericentric Heterochromatin Formation Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Lymphocyte Proliferation Cell Division Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			TGFBR3 expression
Drugs
Diseases
GWAS			Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102) Red cell distribution width ( 32888494) Response to (pegylated) interferon in chronic hepatitis B ( 30715261) Serum alkaline phosphatase levels ( 33547301) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		26 interacting genes: BMI1 BRCA2 CBX8 DECR2 DSCAM EIF4B HELLS LIMS1 LLGL1 MBD3 MTA2 NFE2L2 NONO PCGF2 PML PRMT1 PROM1 RANBP9 RELB RNF2 RPS6KB1 RSPH1 SETDB1 SUMO2 TBL3 UBC	11 interacting genes: APP CEBPA DNMT1 DNMT3B E2F3 GPAT4-AS1 GTSF1L HDAC1 MEOX2 SERTAD2 USP11
Entrez ID		8237	3070
HPRD ID		02081	07232
Ensembl ID		ENSG00000102226	ENSG00000119969
Uniprot IDs		G5E9A6	A0A087WSW7 A0A0B4J1V9 Q0VGL2 Q76H82 Q9NRZ9
PDB IDs			8SKZ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex DNA Methylation-dependent Constitutive Heterochromatin Formation Chromatin Binding Nucleoplasm Negative Regulation Of Apoptotic Signaling Pathway Heterochromatin Regulation Of Apoptotic Signaling Pathway Constitutive Heterochromatin Formation Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Nutrient Chordate Embryonic Development Cellular Response To Methionine Regulation Of DNA-templated Transcription Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Nucleus Response To Methionine Sex Chromatin Regulation Of RNA Biosynthetic Process Heterochromatin Formation Ubiquitin-protein Transferase Activator Activity Regulation Of Primary Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Cytokine Cellular Response To Hydrogen Peroxide Response To Peptide Promoter-specific Chromatin Binding Camera-type Eye Photoreceptor Cell Differentiation Protein Tag Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen-containing Compound	DNA-methyltransferase Activity DNA (cytosine-5-)-methyltransferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Macromolecule Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Chromatin Binding Positive Regulation Of DNA-templated Transcription Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Amyloid-beta Complex Growth Cone Lamellipodium Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Positive Regulation Of Gene Expression Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Heterochromatin Constitutive Heterochromatin Formation DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates Transcription Corepressor Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Muscle Cell Differentiation Promoter-specific Chromatin Binding Acetylcholine Receptor Activator Activity Negative Regulation Of RNA Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Response To Vitamin B2 C/EBP Complex Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Krueppel-associated Box Domain Binding Positive Regulation Of Smooth Muscle Cell Proliferation PTB Domain Binding
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