GNG12

Description		G protein subunit gamma 12
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Membrane Synapse Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Feeling fed-up ( 29500382) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Red cell distribution width ( 32888494) Thyroid stimulating hormone levels ( 32769997) Upper eyelid morphology ( 29921221)
Interacting Genes		7 interacting genes: CAPN1 FHL2 GNB1 GNB2 GNB3 GNB4 HDAC7
Entrez ID		55970
HPRD ID		13592
Ensembl ID		ENSG00000172380
Uniprot IDs		Q9UBI6
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding G Protein-coupled Receptor Signaling Pathway GTPase Activity Protein-containing Complex Binding Lysosomal Membrane Extracellular Exosome Focal Adhesion Atrial Cardiac Muscle Cell Development Calpain Complex Cytoplasm Mammary Gland Involution NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior
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