LAMTOR1 and ABCF3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMTOR1	ABCF3
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	ATP binding cassette subfamily F member 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Late Endosome Membrane Azurophil Granule Membrane Specific Granule Membrane Membrane Raft Extracellular Exosome Ragulator Complex Ficolin-1-rich Granule Membrane FNIP-folliculin RagC/D GAP	Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein-membrane Adaptor Activity GTPase Binding Molecular Adaptor Activity	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Cadherin Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Regulation Of Receptor Recycling Cytoplasmic Translation Endosome Organization Lysosome Organization Intracellular Protein Localization Negative Regulation Of Autophagy Regulation Of Cholesterol Efflux Endosomal Transport Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Lysosome Localization TORC1 Signaling Cholesterol Homeostasis Positive Regulation Of MAPK Cascade Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Cholesterol Import Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Protein Localization To Membrane Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of TORC1 Signaling	Defense Response To Virus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Neutrophil degranulation Regulation of PTEN gene transcription CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Amino acids regulate mTORC1
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Major depressive disorder ( 22472876) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: ABCF3 CAPN1 CCDC90B CTAG1A CTAG1B EEF1A1 NLRP3 TRIM14	20 interacting genes: ACIN1 CCDC33 DLEU1 DNALI1 FBXO7 FCHSD2 HIRIP3 LAMTOR1 MDFI MOCS2 NOA1 PSME3 RBPMS SLC35E1 SPP1 TBPL1 THAP1 TOE1 TRIM14 TRIM27
Entrez ID		55004	55324
HPRD ID		07933	12404
Ensembl ID		ENSG00000149357	ENSG00000161204
Uniprot IDs		Q6IAA8	A0A0S2Z5L1 Q9NUQ8
PDB IDs		5X6U 5X6V 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		TRNA Threonylcarbamoyladenosine Metabolic Process Molecular Adaptor Activity
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