RNF146 and PFN2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RNF146	PFN2
Gene Name		ring finger protein 146	profilin 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Cytoplasm Cytoskeleton Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly-ADP-D-ribose Binding	Adenyl-nucleotide Exchange Factor Activity Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Wnt Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly Regulation Of Synaptic Vesicle Exocytosis
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	Axon guidance Signaling by Robo receptor
Drugs
Diseases
GWAS		Breast cancer ( 18326623) Intracranial volume ( 22504418)
Protein-Protein Interactions		12 interactors: CCDC155 PARP1 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6	31 interactors: ACTB ACTG1 CCDC113 DDX11 DLST DNM1 EEF1A1 EVL FAM173A FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPT5 SGTA SNTA1 SYN1 TERF1 VASP WDR33
Entrez ID		81847	5217
HPRD ID		11511	01451
Ensembl ID		ENSG00000118518	ENSG00000070087
Uniprot IDs		Q9NTX7	G5E9Q6 P35080
PDB IDs		2D8T 3V3L	1D1J
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Poly-ADP-ribosylation Protein K48-linked Ubiquitination Protein Ubiquitination Regulation Of Binding Protein Modification By Small Protein Conjugation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Stress Double-strand Break Repair Protein ADP-ribosylation DNA Repair Protein Catabolic Process Peptidyl-threonine Phosphorylation Cellular Protein Modification Process TRIF-dependent Toll-like Receptor Signaling Pathway Base-excision Repair MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Protein Glycosylation Macromolecule Glycosylation Toll-like Receptor 3 Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Cellular Response To DNA Damage Stimulus Glycosylation Telomere Maintenance Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Glycoprotein Biosynthetic Process Regulation Of DNA Binding Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Glycoprotein Metabolic Process Regulation Of Cellular Localization Cell Cycle Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Toll-like Receptor Signaling Pathway DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Hyperosmotic Salinity Response Regulation Of Growth Rate Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Positive Regulation Of Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Auto-ADP-ribosylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Positive Regulation Of Cellular Component Biogenesis Axonogenesis Movement Of Cell Or Subcellular Component Axon Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Cytoskeleton Organization Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Organelle Organization Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Response To External Stimulus Protein Homooligomerization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Signaling Neuron Differentiation Cell Projection Organization Neuron Projection Development Positive Regulation Of Protein Polymerization Cell Communication Regulation Of Neurotransmitter Levels Actin Cytoskeleton Organization Regulation Of Synaptic Vesicle Exocytosis Regulation Of Actin Cytoskeleton Organization Actin Filament-based Process Platelet Aggregation Neurotransmitter Transport Positive Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Transport Neural Plate Formation Regulation Of Vasoconstriction By Circulating Norepinephrine Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Microvillus Assembly Positive Regulation Of Organelle Organization Cellular Process Positive Regulation Of Stress Fiber Assembly Cellular Component Assembly Positive Regulation Of Actin Filament Bundle Assembly Protein Oligomerization Regulation Of Cellular Component Organization Cell Junction Assembly
Tagcloud ?		adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Difference) ?		adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin	actn1 candidates clonogenic gap gy hcls1 integration integrin itgb5 junction junctions microarray microarrays nci overrepresented platforms postgenome profiling ptprc rab13 radiosensitive radiosensitivity radiosensitization radiotherapy reanalyzed sam set sf2 signature
Tagcloud (Intersection) ?