RNF146 and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		RNF146	UBE2G2
Description		ring finger protein 146	ubiquitin conjugating enzyme E2 G2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Response To Interferon-beta ERAD Pathway Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) LDL cholesterol levels in HIV infection ( 33109212) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alanine aminotransferase levels ( 33547301)
Interacting Genes		12 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6	41 interacting genes: AMFR ARL14 AUP1 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MARCHF6 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF167 RNF168 RNF26 RNF5 TMEM45B TRIM21 TRIM3 TRIM43 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		81847	7327
HPRD ID		11511	04387
Ensembl ID		ENSG00000118518	ENSG00000184787
Uniprot IDs		Q9NTX7	P60604
PDB IDs		2D8T 3V3L 6CF6	2CYX 2KLY 2LXP 3H8K 4LAD 7LEW 8T0S
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Chromosome, Telomeric Region Ubiquitin-protein Transferase Activity Protein Ubiquitination Regulation Of Telomere Capping Spindle Assembly Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Spindle Organization Negative Regulation Of Telomere Maintenance Protein Modification Process Peptidyl-serine Phosphorylation Double-strand Break Repair Positive Regulation Of Protein Phosphorylation DNA Recombination Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly TORC2 Complex Disassembly Oxidized DNA Binding Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Protein Modification Process Positive Regulation Of Actin Filament Bundle Assembly Membraneless Organelle Assembly Damaged DNA Binding Positive Regulation Of Phosphate Metabolic Process Macromolecule Metabolic Process Chromosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Protein Autoubiquitination Negative Regulation Of Protein ADP-ribosylation Negative Regulation Of Chromosome Organization Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric Meiotic Spindle Pole Chromosome Organization ATP Binding Positive Regulation Of Protein Modification Process DNA End Binding Telomere Maintenance Regulation Of Protein Phosphorylation Ku70:Ku80 Complex Regulation Of Stress Fiber Assembly Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Modification Process Catabolic Process Zinc Ion Binding Transferase Activity Protein Metabolic Process Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Metal Ion Binding Macromolecule Metabolic Process ERAD Pathway Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Protein Destabilization Protein K6-linked Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Response To Endoplasmic Reticulum Stress Regulation Of Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Response To Stress Endoplasmic Reticulum Mannose Trimming Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Protein Alpha-1,2-demannosylation Protein K27-linked Ubiquitination Ubiquitin-specific Protease Binding Protein Deglycosylation Positive Regulation Of Dendrite Extension Endoplasmic Reticulum Quality Control Compartment NEDD8 Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling
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