RNF146 and UBE2G2

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		RNF146	UBE2G2
Gene Name		ring finger protein 146	ubiquitin-conjugating enzyme E2G 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Endoplasmic Reticulum Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly-ADP-D-ribose Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Wnt Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Breast cancer ( 18326623) Intracranial volume ( 22504418)
Protein-Protein Interactions		12 interactors: CCDC155 PARP1 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6	37 interactors: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 FARP2 HBS1L HERPUD1 KDM2A KIAA0368 MDM2 MGRN1 MLLT6 MUL1 NDUFS4 PARK2 POLR3F RBX1 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		81847	7327
HPRD ID		11511	04387
Ensembl ID		ENSG00000118518	ENSG00000184787
Uniprot IDs		Q9NTX7	P60604
PDB IDs		2D8T 3V3L	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Poly-ADP-ribosylation Protein K48-linked Ubiquitination Protein Ubiquitination Regulation Of Binding Protein Modification By Small Protein Conjugation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Stress Double-strand Break Repair Protein ADP-ribosylation DNA Repair Protein Catabolic Process Peptidyl-threonine Phosphorylation Cellular Protein Modification Process TRIF-dependent Toll-like Receptor Signaling Pathway Base-excision Repair MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Protein Glycosylation Macromolecule Glycosylation Toll-like Receptor 3 Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Cellular Response To DNA Damage Stimulus Glycosylation Telomere Maintenance Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Glycoprotein Biosynthetic Process Regulation Of DNA Binding Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Glycoprotein Metabolic Process Regulation Of Cellular Localization Cell Cycle Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Toll-like Receptor Signaling Pathway DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Hyperosmotic Salinity Response Regulation Of Growth Rate Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Positive Regulation Of Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Auto-ADP-ribosylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Proteolysis Cellular Protein Metabolic Process Cellular Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Protein Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To Stress Cellular Metabolic Process Regulation Of Proteolysis Regulation Of Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination Cellular Response To Topologically Incorrect Protein Negative Regulation Of Mitochondrial Fusion Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Regulation Of Mitochondrial Fusion Protein Autoubiquitination Response To Stimulus Response To Unfolded Protein Regulation Of Protein Stability Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Cellular Response To Stimulus Response To Organic Substance Positive Regulation Of Mitochondrial Fission Regulation Of Intracellular Signal Transduction Response To Stress Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive e3 elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring ubiquitin
Tagcloud (Difference) ?		adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions	alters assembly attack bond catalyzes chain chains cooperative cooperatively correct cue distal donor drive elusive g2br gp78 helps lys48 monoubiquitin orientation polyubiquitin preassembled preferential thioester transferring
Tagcloud (Intersection) ?		e3 ubiquitin