RNF146

Gene Name		ring finger protein 146
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Gene Ontology Annotations	Cellular Component	Nucleus Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Wnt Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Breast cancer ( 18326623) Intracranial volume ( 22504418)
Protein-protein Interactions		12 interactors: CCDC155 PARP1 PFN2 TGFBR1 TNKS TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		81847
HPRD ID		11511
Ensembl ID		ENSG00000118518
Uniprot IDs		Q9NTX7
PDB IDs		2D8T 3V3L
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Poly-ADP-ribosylation Protein K48-linked Ubiquitination Protein Ubiquitination Regulation Of Binding Protein Modification By Small Protein Conjugation Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Stress Double-strand Break Repair Protein ADP-ribosylation DNA Repair Protein Catabolic Process Peptidyl-threonine Phosphorylation Cellular Protein Modification Process TRIF-dependent Toll-like Receptor Signaling Pathway Base-excision Repair MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Protein Glycosylation Macromolecule Glycosylation Toll-like Receptor 3 Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Cellular Response To DNA Damage Stimulus Glycosylation Telomere Maintenance Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Cellular Metabolic Process Glycoprotein Biosynthetic Process Regulation Of DNA Binding Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Glycoprotein Metabolic Process Regulation Of Cellular Localization Cell Cycle Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Toll-like Receptor Signaling Pathway DNA Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Hyperosmotic Salinity Response Regulation Of Growth Rate Regulation Of Cell Projection Assembly Peptidyl-serine Phosphorylation Positive Regulation Of Binding Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Auto-ADP-ribosylation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction
Tagcloud ?		adp ation axin biology catenin cdk4 classical cyclind1 cycline downregulated e3 enhancing finger g0 invasiveness ligase ligation lymphatic metalloproteinases nsclc promoted ptnm rarely restricted ribosyl staging summary transitions ubiquitin