MRPL38 and PRIM1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		MRPL38	PRIM1
Gene Name		mitochondrial ribosomal protein L38	primase, DNA, polypeptide 1 (49kDa)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Inner Membrane Ribosome	Nucleoplasm Membrane Primosome Complex
	Molecular Function		DNA Primase Activity Metal Ion Binding
	Biological Process	Organelle Organization Mitochondrial Translation Mitochondrial Translational Initiation Mitochondrial Translational Elongation Mitochondrial Translational Termination	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance DNA Replication, Synthesis Of RNA Primer DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Telomere Maintenance Via Semi-conservative Replication
Pathways		Mitochondrial translation Organelle biogenesis and maintenance Mitochondrial translation elongation Mitochondrial translation initiation Mitochondrial translation termination	Activation of the pre-replicative complex Extension of Telomeres Activation of the pre-replicative complex Leading Strand Synthesis DNA strand elongation Polymerase switching DNA replication initiation Telomere Maintenance G1/S Transition Mitotic G1-G1/S phases E2F mediated regulation of DNA replication Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand DNA Replication Pre-Initiation M/G1 Transition Telomere C-strand (Lagging Strand) Synthesis S Phase Cell Cycle, Mitotic Removal of the Flap Intermediate Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201)
Protein-Protein Interactions		6 interactors: C14orf1 CSNK2A1 DOCK8 HSPB3 PRIM1 PRMT6	3 interactors: MDC1 MRPL38 TP53
Entrez ID		64978	5557
HPRD ID		14758	08899
Ensembl ID		ENSG00000204316	ENSG00000198056
Uniprot IDs		Q96DV4	P49642
PDB IDs			4BPU 4BPW 4BPX
Enriched GO Terms of Interacting Partners?			Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Double-strand Break Repair DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Negative Regulation Of Helicase Activity Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Mitochondrial DNA Repair Mitochondrion Organization Regulation Of Mitotic Cell Cycle Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Cell Cycle ER Overload Response Intra-S DNA Damage Checkpoint Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process DNA Repair Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Mitotic Cell Cycle Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription T Cell Lineage Commitment Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod
Tagcloud ?		arose ccl8 cfl1 consistently cox8b eif4a eif4b fourfold hoxd13 immature lbl leukemias leukemic littermates lmo1 lymphoblastic nhd13 nup98 okadaic overexpressed pbx3 prss16 situation tcra tcrb thymic thymocytes transgenic underexpressed
Tagcloud (Difference) ?		arose ccl8 cfl1 consistently cox8b eif4a eif4b fourfold hoxd13 immature lbl leukemias leukemic littermates lmo1 lymphoblastic nhd13 nup98 okadaic overexpressed pbx3 prss16 situation tcra tcrb thymic thymocytes transgenic underexpressed
Tagcloud (Intersection) ?