MRPL38 and PRIM1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		MRPL38	PRIM1
Description		mitochondrial ribosomal protein L38	DNA primase subunit 1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Cytosol Ribosome Ribonucleoprotein Complex	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane
	Molecular Function	Protein Binding	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding
	Biological Process	Mitochondrial Translation	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		White matter hyperintensities ( 30002152)	Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)
Interacting Genes		21 interacting genes: ARHGAP9 BAG3 BEX2 BTG3 CCDC120 CENATAC CSNK2A1 DOCK8 ENKD1 ERCC6 ERG28 GOLGA6A HSPB3 LONRF1 MKRN3 MYOZ3 PPP1R18 PRIM1 RALY TSEN54 UBC	5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53
Entrez ID		64978	5557
HPRD ID		14758	08899
Ensembl ID		ENSG00000204316	ENSG00000198056
Uniprot IDs		Q96DV4	P49642
PDB IDs		3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5H 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OI6 7OI7 7OI8 7OI9 7OIA 7OIB 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8PK0 8QSJ 8QU1 8QU5 8RRI 8XT0 8XT1 8XT2 8XT3	4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Aggrephagy Double-strand Break Repair Via Classical Nonhomologous End Joining	Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy
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