RHOJ and DOCK10

Number of citations of the paper that reports this interaction (PubMedID 15710388)
0

Data Source:
HPRD (in vitro)

		RHOJ	DOCK10
Description		ras homolog family member J	dedicator of cytokinesis 10
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Cell Projection Dendritic Spine Synapse Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Angiogenesis Endocytosis Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Establishment Of Cell Polarity Actin Cytoskeleton Organization Retina Vasculature Morphogenesis In Camera-type Eye Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis	B Cell Homeostasis Marginal Zone B Cell Differentiation Small GTPase-mediated Signal Transduction Regulation Of Cell Migration Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Dendritic Spine Morphogenesis Regulation Of Postsynapse Assembly
Pathways		RHOJ GTPase cycle	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Endometriosis ( 28881265) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483)	Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Granulocyte percentage of myeloid white cells ( 27863252) IgE levels in asthmatics (D.p. specific) ( 23967269) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 32888494) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple sclerosis ( 31604244) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Response to bupropion and depression ( 27622933) Response to exercise (triglyceride level interaction) ( 26491034) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		22 interacting genes: ACVR1 ADAMTSL4 BHLHE40 BLZF1 BMPR1B CDC42 DOCK10 DOCK8 GOLGA2 MEOX2 PAK1 PAK3 PAK5 PAK6 PARD6B SMAD2 SMAD4 SSX3 TGFBR1 TRIP10 WAS ZNF426	5 interacting genes: CCDC102B CFTR LURAP1 MAGEA11 RHOJ
Entrez ID		57381	55619
HPRD ID		09632	10919
Ensembl ID		ENSG00000126785	ENSG00000135905
Uniprot IDs		Q7Z513 Q9H4E5	A0A2R8YD85 Q96BY6
PDB IDs			6TKY 6TKZ 6TM1 7Q43
Enriched GO Terms of Interacting Partners?		SMAD Binding Transforming Growth Factor Beta Receptor Activity, Type I Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Pattern Specification Process Protein Serine/threonine Kinase Activity Anatomical Structure Morphogenesis Cell Migration Ameboidal-type Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Regionalization Cell Projection Morphogenesis Neuron Projection Morphogenesis I-SMAD Binding Dendritic Spine Morphogenesis Protein Kinase Activity Regulation Of Cell Motility Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Motility Roof Of Mouth Development Regulation Of Locomotion Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Projection Organization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Activin Responsive Factor Complex Regulation Of Actin Filament-based Process Intracellular Signaling Cassette Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Kinase Activity Cellular Response To BMP Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Dendritic Spine Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cell Migration Ventricular Septum Morphogenesis Regulation Of Actin Filament Organization Positive Regulation Of SMAD Protein Signal Transduction Tissue Development Neuron Projection Organization Postsynapse Organization Gastrulation Activin Receptor Complex Activin Receptor Activity, Type I SMAD Protein Complex Trophoblast Cell Migration Positive Regulation Of Stress Fiber Assembly	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Retina Vasculature Morphogenesis In Camera-type Eye Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Centriole-centriole Cohesion Golgi-associated Vesicle Membrane Cellular Response To Forskolin
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