EPHA3 and EFNA5

Number of citations of the paper that reports this interaction (PMID 9195962)
16

Data Source:
BioGRID (biochemical)
HPRD (in vitro, in vivo)

		EPHA3	EFNA5
Gene Name		EPH receptor A3	ephrin-A5
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Early Endosome Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane
	Molecular Function	GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding	Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Cell Adhesion Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Orofacial clefts ( 22863734)	Alzheimer's disease biomarkers ( 23419831) Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		20 interactors: ABL1 ADAM10 CDKN2A CRK EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 FYN PIM1 RBM18 RUFY1 RUFY2 SRC SRPK1 STAT3 TP53	10 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC
Entrez ID		2042	1946
HPRD ID		01555	03324
Ensembl ID		ENSG00000044524	ENSG00000184349
Uniprot IDs		C9JXA2 P29320 Q6P4R6	P52803
PDB IDs		2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4	2X11 3MX0 4BK5 4BKA
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Differentiation Neuron Projection Development Cell Projection Morphogenesis Generation Of Neurons Cell Part Morphogenesis Neurogenesis Neuron Development Cell Development Cell Morphogenesis Movement Of Cell Or Subcellular Component Cell Projection Organization Locomotion Nervous System Development Response To External Stimulus Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Cell Differentiation Signal Transduction Developmental Process Regulation Of Cell Adhesion Signaling Cell Communication Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Phosphorylation Multicellular Organismal Development Regulation Of Cell-cell Adhesion Regulation Of Cellular Component Organization Anatomical Structure Development Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation System Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Positive Regulation Of Phosphorylation	Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Neuron Projection Development Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Peptidyl-amino Acid Modification Neurogenesis Cell Morphogenesis Cell Development Locomotion Protein Phosphorylation Nervous System Development Movement Of Cell Or Subcellular Component Response To External Stimulus Phosphorylation Cell Differentiation Anatomical Structure Morphogenesis System Development Regulation Of Intracellular Signal Transduction Retinal Ganglion Cell Axon Guidance Phosphate-containing Compound Metabolic Process Regulation Of MAPK Cascade Axonal Fasciculation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cellular Protein Modification Process Fasciculation Of Motor Neuron Axon Anatomical Structure Development Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Cell Migration Fasciculation Of Sensory Neuron Axon Developmental Process Cell Motility Signaling
Tagcloud ?		arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Difference) ?		arid2 asxl3 cdkn2a clonal clone dipyrimidine driver extension founding geographic hypermutator lacked mel9 melanoma mll2 nras phosphatases ptprb ptprd ptprt rb1 signature strikingly subclonal subclones suppressors transitions truncation wgs	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Intersection) ?