EPHA3 and EFNA2

Number of citations of the paper that reports this interaction (PubMedID 9751130)
0

Data Source:
HPRD (in vivo, in vitro)

		EPHA3	EFNA2
Description		EPH receptor A3	ephrin A2
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Actin Cytoskeleton Membrane Dendrite Nuclear Membrane	Plasma Membrane Membrane Neuromuscular Junction Perikaryon Side Of Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Protein Binding Ephrin Receptor Binding
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane	Cell-cell Signaling Axon Guidance Olfactory Bulb Development Osteoclast Differentiation Bone Remodeling Ephrin Receptor Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Language functional connectivity ( 34929384) Lateral thalamic nuclei volume ( 34006833) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Ventral thalamic nuclei volume ( 34006833) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324)	Response to selenium supplementation (change in plasma selenium concentration) ( 33382417)
Interacting Genes		30 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RNF5 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE	5 interacting genes: ADAM10 EPHA2 EPHA3 EPHA5 ZHX1
Entrez ID		2042	1943
HPRD ID		01555	04132
Ensembl ID		ENSG00000044524	ENSG00000099617
Uniprot IDs		A0A140VJJ0 C9JXA2 P29320 Q6P4R6	O43921
PDB IDs		2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0	2WO3
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization T Cell Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Growth SH2 Domain Binding Response To Hydrogen Peroxide Protein Modification Process Regulation Of Anatomical Structure Morphogenesis Cell Projection Organization T Cell Costimulation Regulation Of Vasculature Development Positive Regulation Of Intracellular Signal Transduction Lymphocyte Proliferation Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Development Mononuclear Cell Proliferation Side Of Membrane Regulation Of Lymphocyte Activation Cell Population Proliferation Regulation Of Protein Stability Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Proliferation Leukocyte Activation Cellular Response To Transforming Growth Factor Beta Stimulus Phosphoprotein Phosphatase Activity Regulation Of Cell Growth Regulation Of Phosphorus Metabolic Process Signaling Receptor Binding Cellular Response To Hydrogen Peroxide Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Neuron Projection Development Regulation Of Biological Quality Response To Reactive Oxygen Species Negative Regulation Of Hydrogen Peroxide Biosynthetic Process	Ephrin Receptor Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Signaling Pathway GPI-linked Ephrin Receptor Activity Regulation Of Cellular Localization Protein Tyrosine Kinase Activity Regulation Of GTPase Activity Regulation Of Protein Localization To Cell Periphery Transmembrane-ephrin Receptor Activity Regulation Of Protein Localization To Membrane Regulation Of Protein Localization Positive Regulation Of Protein Localization To Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Dendrite Positive Regulation Of Protein Localization To Cell Periphery Protein Kinase Activity Positive Regulation Of Protein Localization To Membrane Constitutive Protein Ectodomain Proteolysis Notochord Cell Development Regulation Of Catalytic Activity Kinase Activity Regulation Of Protein Localization To Plasma Membrane Epidermal Growth Factor Receptor Ligand Maturation Enzyme-linked Receptor Protein Signaling Pathway Axial Mesoderm Formation Fasciculation Of Motor Neuron Axon Cell Surface Receptor Signaling Pathway Protein Catabolic Process At Postsynapse Negative Regulation Of Lymphangiogenesis Notochord Formation Fasciculation Of Sensory Neuron Axon Regulation Of Cell Adhesion Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Neuron Projection Guidance Axon Guidance Notochord Morphogenesis Pericyte Cell Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Cellular Component Organization Lens Fiber Cell Morphogenesis Metallodipeptidase Activity Regulation Of Cell Junction Assembly Tetraspanin-enriched Microdomain Positive Regulation Of CREB Transcription Factor Activity Monocyte Activation Leading Edge Membrane Positive Regulation Of Bicellular Tight Junction Assembly Cell Projection Regulation Of Vasculature Development Pore Complex
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