EPHA3 and ADAM10

Number of citations of the paper that reports this interaction (PubMedID 16239146)
0

Data Source:
HPRD (in vitro)

		EPHA3	ADAM10
Description		EPH receptor A3	ADAM metallopeptidase domain 10
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Early Endosome Cytosol Plasma Membrane Actin Cytoskeleton Membrane Dendrite Nuclear Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Lumen Golgi Apparatus Golgi-associated Vesicle Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Postsynaptic Density Membrane Clathrin-coated Vesicle Axon Dendrite Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Pore Complex Extracellular Exosome Anchoring Junction Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum Synaptic Membrane Tetraspanin-enriched Microdomain Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity SH3 Domain Binding Protein Kinase Binding Protein Homodimerization Activity Metal Ion Binding Metallodipeptidase Activity Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Actin Cytoskeleton Organization Regulation Of GTPase Activity Negative Regulation Of Endocytosis Ephrin Receptor Signaling Pathway Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Retinoic Acid Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Positive Regulation Of Protein Localization To Plasma Membrane	In Utero Embryonic Development Proteolysis Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of T Cell Chemotaxis Protein Processing Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Adherens Junction Organization Response To Tumor Necrosis Factor Epidermal Growth Factor Receptor Ligand Maturation Monocyte Activation Amyloid Precursor Protein Catabolic Process Pore Complex Assembly Constitutive Protein Ectodomain Proteolysis Cochlea Development Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynapse Organization Regulation Of Postsynapse Organization Protein Catabolic Process At Postsynapse Signaling Receptor Ligand Precursor Processing Regulation Of Vasculature Development Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Collagen degradation Degradation of the extracellular matrix Signaling by EGFR Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation
Drugs		Fostamatinib	XL784
Diseases
GWAS		Adult body size ( 32376654) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from tea ( 33287642) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878) Language functional connectivity ( 34929384) Lateral thalamic nuclei volume ( 34006833) Loneliness (multivariate analysis) ( 27629369) Lung function (FVC) ( 26635082) Orofacial clefts ( 22863734) Periodontitis (Mean PAL) ( 24024966) Post-bronchodilator FEV1 x air pollution (NO2) interaction in childhood asthma ( 31028280) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878) Tea consumption ( 31046077) Thrombosis ( 26908601) Ventral thalamic nuclei volume ( 34006833) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Weight ( 34074324)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 30617256 33589840) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Diffusing capacity of carbon monoxide ( 30694715) Family history of Alzheimer's disease ( 30617256) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Metabolite levels ( 23823483) Schizophrenia ( 30285260)
Interacting Genes		30 interacting genes: ABL1 ADAM10 CDKN2A CRK CTDSP2 DUSP18 DUSP21 EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EFNB1 EFNB2 ERBB2 FBXO7 FYN ILKAP MTMR11 PIM1 RBM18 RNF5 RUFY1 RUFY2 SRC SRPK1 STAT3 STYX TP53 TPTE	7 interacting genes: AXL DLL1 EFNA1 EFNA2 EPHA3 SH3D19 TGFA
Entrez ID		2042	102
HPRD ID		01555	03723
Ensembl ID		ENSG00000044524	ENSG00000137845
Uniprot IDs		A0A140VJJ0 C9JXA2 P29320 Q6P4R6	O14672
PDB IDs		2GSF 2QO2 2QO7 2QO9 2QOB 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ 3DZQ 3FXX 3FY2 4G2F 4GK2 4GK3 4GK4 4L0P 4P4C 4P5Q 4P5Z 4TWN 4TWO 6IN0	6BDZ 6BE6 8ESV
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Binding Ephrin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Neuron Projection Guidance Axon Guidance Neuron Projection Development Regulation Of Cell Adhesion Regulation Of Cellular Component Organization Plasma Membrane Bounded Cell Projection Organization T Cell Proliferation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Growth SH2 Domain Binding Response To Hydrogen Peroxide Protein Modification Process Regulation Of Anatomical Structure Morphogenesis Cell Projection Organization T Cell Costimulation Regulation Of Vasculature Development Positive Regulation Of Intracellular Signal Transduction Lymphocyte Proliferation Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Development Mononuclear Cell Proliferation Side Of Membrane Regulation Of Lymphocyte Activation Cell Population Proliferation Regulation Of Protein Stability Regulation Of Developmental Process Regulation Of Catalytic Activity Regulation Of T Cell Activation Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Proliferation Leukocyte Activation Cellular Response To Transforming Growth Factor Beta Stimulus Phosphoprotein Phosphatase Activity Regulation Of Cell Growth Regulation Of Phosphorus Metabolic Process Signaling Receptor Binding Cellular Response To Hydrogen Peroxide Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Signal Transduction Response To Transforming Growth Factor Beta Regulation Of Neuron Projection Development Regulation Of Biological Quality Response To Reactive Oxygen Species Negative Regulation Of Hydrogen Peroxide Biosynthetic Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Cell Surface Receptor Signaling Pathway Neuron Projection Guidance Axon Guidance Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Endocytosis Regulation Of Developmental Process Regulation Of Cell Adhesion Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Cerebellar Molecular Layer Formation Regulation Of Cell Differentiation Leukocyte Differentiation Tissue Remodeling Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Fasciculation Of Motor Neuron Axon Endothelial Tip Cell Fate Specification Cerebellar Purkinje Cell Layer Structural Organization Positive Regulation Of Cellular Component Organization Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Plasma Membrane Neuron Projection Development Notochord Formation Endocardial Cushion To Mesenchymal Transition Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Side Of Membrane Fasciculation Of Sensory Neuron Axon Receptor Ligand Activity Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Compartment Pattern Specification Lateral Inhibition Blood Vessel Endothelial Cell Fate Specification Endothelial Cell Fate Specification Regulation Of Vesicle-mediated Transport Positive Regulation Of Skeletal Muscle Tissue Growth Loop Of Henle Development Somite Specification Positive Regulation Of Endocytosis Positive Regulation Of Pinocytosis Kinase Activity Neutrophil Clearance Cell-substrate Adhesion
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