RAB39B

Description		RAB39B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Neuron Projection Autolysosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Autophagy Regulation Of Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Synapse Organization
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Interacting Genes		6 interacting genes: GOLGA2 RAB3GAP1 RUFY1 SGSM3 VPS26C ZDHHC17
Entrez ID		116442
HPRD ID		06703
Ensembl ID		ENSG00000155961
Uniprot IDs		Q96DA2
PDB IDs		6S5F
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Cellular Localization Endosomal Transport Small GTPase-mediated Signal Transduction Cis-Golgi Network Protein Transport Vesicle-mediated Transport Intracellular Transport Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of GTPase Activity Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Hydrolase Activity Regulation Of Vesicle-mediated Transport Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Establishment Of Localization In Cell Regulation Of GTPase Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Glycosylation Intracellular Protein Localization Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Rab Protein Signal Transduction Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Protein Metabolic Process Golgi Disassembly Protein-cysteine S-stearoyltransferase Activity Intracellular Signaling Cassette Regulation Of Protein Glycosylation Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Importin-alpha Family Protein Binding Regulation Of Organelle Assembly GTPase Activator Activity Golgi Ribbon Formation Rap Protein Signal Transduction Plasma Membrane To Endosome Transport Golgi Cis Cisterna Golgi Vesicle Transport Small GTPase Binding Positive Regulation Of Glutamate Secretion Regulation Of Neurotrophin TRK Receptor Signaling Pathway Asymmetric Cell Division Positive Regulation Of Catalytic Activity Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity
Tagcloud ?