RAB39B and VPS26C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RAB39B	VPS26C
Description		RAB39B, member RAS oncogene family	VPS26 endosomal protein sorting factor C
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Neuron Projection Autolysosome Membrane	Nucleus Endosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding	Protein Binding
	Biological Process	Autophagy Regulation Of Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Synapse Organization	Intracellular Protein Transport Endocytic Recycling
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS
Interacting Genes		6 interacting genes: GOLGA2 RAB3GAP1 RUFY1 SGSM3 VPS26C ZDHHC17	44 interacting genes: AGTPBP1 ARHGAP21 ASH1L CBLB CCDC85A CIPC DCLK1 DDIT4L DECR2 DNAJB2 EPHB6 INCA1 KIF1A KIF21A LRIF1 MAML3 MAPK6 MAPK8IP1 MDM4 MEI4 MEOX2 MRPS35 MYRIP NRCAM NSMF PALS2 PCM1 PEG10 PMS2 PRKD2 PTPN21 RAB39B RAP1GAP RAP1GAP2 SETMAR TAF1C TEPSIN TET2 TRAPPC1 U2AF1 VPS26A VPS35L XPA ZNF655
Entrez ID		116442	10311
HPRD ID		06703	10390
Ensembl ID		ENSG00000155961	ENSG00000157538
Uniprot IDs		Q96DA2	A8MTY9 A8MY26 O14972
PDB IDs		6S5F	8P0X 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Establishment Of Protein Localization Cellular Localization Endosomal Transport Small GTPase-mediated Signal Transduction Cis-Golgi Network Protein Transport Vesicle-mediated Transport Intracellular Transport Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of GTPase Activity Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Hydrolase Activity Regulation Of Vesicle-mediated Transport Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Establishment Of Localization In Cell Regulation Of GTPase Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Glycosylation Intracellular Protein Localization Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Rab Protein Signal Transduction Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Protein Metabolic Process Golgi Disassembly Protein-cysteine S-stearoyltransferase Activity Intracellular Signaling Cassette Regulation Of Protein Glycosylation Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Importin-alpha Family Protein Binding Regulation Of Organelle Assembly GTPase Activator Activity Golgi Ribbon Formation Rap Protein Signal Transduction Plasma Membrane To Endosome Transport Golgi Cis Cisterna Golgi Vesicle Transport Small GTPase Binding Positive Regulation Of Glutamate Secretion Regulation Of Neurotrophin TRK Receptor Signaling Pathway Asymmetric Cell Division Positive Regulation Of Catalytic Activity Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity
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