TM2D3 and PAXIP1

Number of citations of the paper that reports this interaction (PubMedID 22990118)
93

Data Source:
BioGRID (two hybrid)

		TM2D3	PAXIP1
Description		TM2 domain containing 3	PAX interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nucleoplasm Chromosome Nuclear Matrix Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function		Protein Binding
	Biological Process	Positive Regulation Of Notch Signaling Pathway Lateral Inhibition	Vasculogenesis DNA Repair DNA Recombination Chromatin Remodeling DNA Damage Response Response To Ionizing Radiation DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Endothelial Cell Migration Positive Regulation Of Isotype Switching Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Transcription Initiation By RNA Polymerase II Adipose Tissue Development Chorion Development Regulation Of Cell Cycle G2/M Phase Transition
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis Nonhomologous End-Joining (NHEJ) Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Depression in multiple sclerosis (pre-diagnosis) ( 33296963) Triglyceride levels ( 32154731)	Bladder cancer (smoking interaction) ( 24662972) Metabolite levels ( 23823483)
Interacting Genes		3 interacting genes: ERRFI1 LCOR PAXIP1	90 interacting genes: A2M APP ATP1B1 ATP1B3 BTBD16 BTBD6 C2orf42 CABYR CATSPERG CBX8 CCNDBP1 CIAO2B CLU COMTD1 CYB5R4 DCP1A DIS3L DNAJA1 DNAJB11 DYNC2H1 ECSIT EIF3I EIF5B EP300 EPB41L3 FAHD1 FBLN5 FUCA1 H2AX H3C1 HNRNPLL HSPA14 HSPA4L INTS7 LACTB MAPRE2 MAST1 MRPL33 MT-ND1 MT2A MTIF3 MTNR1A NOS3 NPC2 NUPR1 PAGR1 PAX2 PCBP2 PCYT1B PGGHG PGM1 PIAS1 PIAS2 PKP4 PLCD1 PML POM121 PPHLN1 PPIA PPP2R5C PRDX6 PSMA6 RNF32 RPA1 RPL12 RPS20 RPS27A SCAMP5 SCCPDH SELENOV SH3GL2 SMAD2 SNX3 SOX30 SPAG4 SPATA18 SUGT1 SUZ12 TCN2 TECR TM2D3 TMEM120A TP53BP1 TRAPPC8 UMPS WDR48 XAGE1B ZBTB8A ZNF251 ZNF280B
Entrez ID		80213	22976
HPRD ID		16554	08491
Ensembl ID		ENSG00000184277	ENSG00000157212
Uniprot IDs		B4DLL2 E7EPS7 H0YNS4 Q9BRN9	Q6ZW49
PDB IDs			3SQD
Enriched GO Terms of Interacting Partners?		Ubiquitin-specific Protease Binding Adipose Tissue Development Connective Tissue Development Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Cellular Response To Lipid Response To Estradiol Cellular Response To Insulin Stimulus Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Derlin-1-VIMP Complex Intracellular Signal Transduction Chorion Development Negative Regulation Of Protein Autophosphorylation Anatomical Structure Homeostasis Tissue Homeostasis Cellular Response To Peptide Hormone Stimulus Oviduct Epithelium Development Regulation Of Tumor Necrosis Factor Production Response To Insulin Threonine-tRNA Ligase Activity Threonyl-tRNA Aminoacylation Response To Lipid Limb Joint Morphogenesis Cellular Response To Oxygen-containing Compound Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Macrophage Apoptotic Process Osteoclast Development MLL3/4 Complex Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Negative Regulation Of Cytokine Production Response To Peptide Hormone Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Cellular Response To Chemical Stress Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Cellular Response To Hormone Stimulus ER Overload Response Negative Regulation Of Acute Inflammatory Response	Regulation Of Cellular Response To Stress Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Cytoplasm Protein-DNA Complex
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