NUP214 and XPO5

Number of citations of the paper that reports this interaction (PubMedID 11777942)
42

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NUP214	XPO5
Description		nucleoporin 214	exportin 5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex RNA Nuclear Export Complex
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	TRNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding Pre-miRNA Binding RISC Complex Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle	RNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport MiRNA Metabolic Process Protein Transport Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Export From Nucleus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	Hemoglobin levels ( 32327693) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36	10 interacting genes: CEBPA EEF1A1 FADD ILF3 NUP153 NUP214 RAN SMAD4 SUMO2 ZNF346
Entrez ID		8021	57510
HPRD ID		00258	06385
Ensembl ID		ENSG00000126883	ENSG00000124571
Uniprot IDs		B7ZAV2 P35658	Q9HAV4
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K	3A6P 5YU6 5YU7
Enriched GO Terms of Interacting Partners?		RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery	Nucleolus Protein-containing Complex Binding Regulation Of Protein Catabolic Process Interleukin-6-mediated Signaling Pathway RNA Export From Nucleus Nuclear Export Signal Receptor Activity Nuclear Export Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Import Into Nucleus Nuclear Pore Regulation Of Protein Metabolic Process RNA Transport Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding Protein Localization To Nucleus Protein Export From Nucleus Positive Regulation Of Proteolysis Nucleobase-containing Compound Transport Nucleoplasm Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Regulation Of Intracellular Transport Gland Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Cytoplasmic Side Of Nuclear Pore Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Protein-containing Complex Double-stranded RNA Binding Establishment Of Protein Localization To Organelle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex RNA Binding Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Death-inducing Signaling Complex Assembly Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?