NUP214 and NUP107

Number of citations of the paper that reports this interaction (PubMedID 9166401)
59

Data Source:
HPRD (in vivo)

		NUP214	NUP107
Description		nucleoporin 214	nucleoporin 107
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Chromosome Cytosol Membrane Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Female Gonad Development Protein Transport MRNA Transport Nuclear Pore Complex Assembly Nephron Development
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	White blood cell count ( 20139978)
Interacting Genes		19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36	4 interacting genes: APAF1 NUP133 NUP214 SUMO2
Entrez ID		8021	57122
HPRD ID		00258	06356
Ensembl ID		ENSG00000126883	ENSG00000111581
Uniprot IDs		B7ZAV2 P35658	P57740
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K	3CQC 3CQG 3I4R 5A9Q 7PEQ 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery	Structural Constituent Of Nuclear Pore Response To G1 DNA Damage Checkpoint Signaling RNA Export From Nucleus Cytoplasmic Side Of Nuclear Pore MRNA Export From Nucleus Nuclear Pore Protein Import Into Nucleus Import Into Nucleus MRNA Transport Nuclear Export RNA Transport Apoptosome Protein Localization To Nucleus Nucleobase-containing Compound Transport Nuclear Envelope Response To DNA Damage Checkpoint Signaling Nuclear Transport Nucleocytoplasmic Transport Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Paraxial Mesoderm Development Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Nuclear Pore Outer Ring Cardiac Muscle Cell Apoptotic Process Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Establishment Of Protein Localization To Organelle Nuclear Export Signal Receptor Activity Nephron Development Striated Muscle Cell Apoptotic Process Nuclear Pore Organization Protein Tag Activity Somite Development Muscle Cell Apoptotic Process SUMO Transferase Activity Nuclear Localization Sequence Binding Poly(A)+ MRNA Export From Nucleus Ubiquitin-like Protein Ligase Binding Presynaptic Cytosol Postsynaptic Cytosol Intracellular Protein Transport Protein Export From Nucleus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Peptidyl-prolyl Cis-trans Isomerase Activity
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