NUP214 and NUP88

Number of citations: 57 (PubMedID 9488438)
Data Source: BioGRID (cross-linking study), HPRD (in vitro)

		NUP214	NUP88
Name		nucleoporin 214	nucleoporin 88
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport MRNA Transport
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
GWAS		Aspartate aminotransferase levels ( 31219225 )	Adult body size ( 32376654 ) Lymphocyte count ( 32888494 ) Mean platelet volume ( 32888494 )
Novel Interactors		11 novel interactors: ASS1 CHST6 DYNC1I1 LSS MRPS6 NCBP1 NUP98 POMT1 PRRX2 STOM VAV2	3 novel interactors: DVL2 EFNB3 EOLA1
Interacting Genes		19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36	5 interacting genes: AGTR1 CD82 NUP214 NUP98 TFIP11
Entrez ID		8021	4927
HPRD ID		00258	03974
Ensembl ID		ENSG00000126883	ENSG00000108559
Uniprot IDs		B7ZAV2 P35658	B4DP20 J3KMX1 Q99567
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K	7MNI 7R5J 7R5K
GO Terms Enriched among Interactors		RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery	Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Angiotensin Type I Receptor Activity Symbiont Entry Into Host Cell Phospholipase C-activating Angiotensin-activated Signaling Pathway Bradykinin Receptor Binding Renin-angiotensin Regulation Of Aldosterone Production Convergent Extension Involved In Neural Plate Elongation Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission RNA Export From Nucleus Nuclear Export Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Telomere Tethering At Nuclear Periphery Import Into Nucleus MRNA Transport Protein Import Into Nucleus Nuclear Pore Cytoplasmic Side Of Nuclear Pore Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Angiotensin Type II Receptor Activity Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Biological Process Involved In Interaction With Host Convergent Extension Involved In Organogenesis RNA Transport Nuclear Pore Cytoplasmic Filaments Convergent Extension Involved In Gastrulation Trans-synaptic Signaling By Trans-synaptic Complex Axon Choice Point Recognition Protein Localization To Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protection From Non-homologous End Joining At Telomere Regulation Of Renal Sodium Excretion Positive Regulation Of Neuron Projection Arborization Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Telomere Localization Nuclear Envelope Nucleobase-containing Compound Transport Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Trans-synaptic Signaling, Modulating Synaptic Transmission Nuclear Transport Nucleocytoplasmic Transport Nuclear Inclusion Body Nuclear Export Signal Receptor Activity Convergent Extension Nuclear Pore Nuclear Basket Nuclear Pore Organization