NUP214 and NCBP1

		NUP214	NCBP1
Description		nucleoporin 214	nuclear cap binding protein subunit 1
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Nuclear Cap Binding Complex RNA Cap Binding Complex Ribonucleoprotein Complex
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding Molecular Adaptor Activity
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Spliceosomal Complex Assembly Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Cap-dependent Translational Initiation 7-methylguanosine MRNA Capping MRNA Processing RNA Catabolic Process MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translation Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing RNA Metabolic Process MRNA Metabolic Process Positive Regulation Of Cell Growth Regulatory NcRNA-mediated Gene Silencing Primary MiRNA Processing MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Transport Defense Response To Virus Positive Regulation Of RNA Binding
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nuclear RNA decay
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36	19 interacting genes: BNIP1 BNIP2 BNIP3 DSCR9 EIF4G1 EIF4G2 HNRNPF HNRNPH1 LINC01554 NCBP2 PSTPIP1 PTEN RNF10 RNF20 RNF40 RPS6KB1 SNRPA1 STAU1 ZDHHC17
Entrez ID		8021	4686
HPRD ID		00258	02717
Ensembl ID		ENSG00000126883	ENSG00000136937
Uniprot IDs		B7ZAV2 P35658	Q09161
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y 7ABG 8BY6 8PMP 8PNT 8SRR 8SUY
Enriched GO Terms of Interacting Partners?		RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery	Response To Oxygen-glucose Deprivation Regulation Of Translational Initiation HULC Complex Cap-dependent Translational Initiation Nuclear Envelope Multicellular Organismal Response To Stress Translational Initiation Eukaryotic Translation Initiation Factor 4F Complex MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Macromolecule Catabolic Process Catalytic Step 2 Spliceosome Regulation Of Cell Cycle Response To Nutrient Levels Macromolecule Metabolic Process Negative Regulation Of Autophagy Regulation Of Mitotic Cell Cycle Translation Factor Activity, RNA Binding MRNA Binding Ubiquitin-specific Protease Binding Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Cell Death Post-transcriptional Regulation Of Gene Expression Cytoplasmic Translational Initiation Regulation Of Autophagy Protein Metabolic Process Mitochondrion Autophagosome Adaptor Activity Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Fear Response Behavioral Fear Response Behavioral Defense Response RNA Splicing Negative Regulation Of Synaptic Vesicle Clustering Proteolysis Involved In Protein Catabolic Process Cytoplasmic Side Of Nuclear Pore Perforant Pathway To Dendrate Granule Cell Synapse Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Spliceosomal Complex Regulation Of Translation RNA Binding Translation Initiation Factor Activity MRNA Processing Mitochondrial Outer Membrane Apoptotic Process In Response To Mitochondrial Fragmentation Cellular Response To Oxidative Stress Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
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