XPO5 and RAN

Number of citations of the paper that reports this interaction (PMID 11777942)
49

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		XPO5	RAN
Gene Name		exportin 5	RAN, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Melanosome Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	TRNA Binding RNA Binding Protein Binding Ran GTPase Binding Protein Transporter Activity Poly(A) RNA Binding	Chromatin Binding Transcription Coactivator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Poly(A) RNA Binding Androgen Receptor Binding
	Biological Process	Protein Export From Nucleus Gene Expression Gene Silencing By RNA	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Metabolic Process Protein Import Into Nucleus Protein Export From Nucleus Mitotic Spindle Organization Mitotic Nuclear Division Signal Transduction Small GTPase Mediated Signal Transduction Spermatid Development Gene Expression Viral Process Viral Life Cycle Actin Cytoskeleton Organization Androgen Receptor Signaling Pathway Positive Regulation Of Protein Binding Cellular Protein Complex Localization Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Cell Division Intracellular Transport Of Virus
Pathways		Regulatory RNA pathways MicroRNA (miRNA) biogenesis	Transcriptional regulation by small RNAs Metabolism of lipids and lipoproteins Nuclear import of Rev protein HIV Infection Regulatory RNA pathways Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors MicroRNA (miRNA) biogenesis Influenza Infection Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Export of Viral Ribonucleoproteins from Nucleus HIV Life Cycle Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: EEF1A1 FADD ILF3 NUP153 NUP214 RAN SMAD4 ZNF346	55 interactors: ABL1 ADRB2 AR ASAP2 BCAR1 BMPR1B CSE1L EP300 GADD45G GIT1 IPO11 IPO13 IPO5 IPO7 KIAA1377 KPNA2 KPNB1 MBP MSL1 NEK9 NR3C1 NSMF NUP153 NUP50 NUPR1 NUTF2 NXF1 NXT1 PAK4 PTMA RANBP1 RANBP10 RANBP2 RANBP3 RANBP9 RANGAP1 RANGRF RCC1 RGPD5 RPL7 SMAD1 SMAD2 SMARCB1 SMURF2 SNUPN SPAG8 SSRP1 TGFBR1 TNPO1 TNPO2 XPO1 XPO4 XPO5 XPO7 XPOT
Entrez ID		57510	5901
HPRD ID		06385	03109
Ensembl ID		ENSG00000124571
Uniprot IDs		Q9HAV4	B4DV51 P62826
PDB IDs		3A6P	1I2M 1IBR 1K5D 1K5G 1QBK 1RRP 3CH5 3EA5 3GJ0 3GJ3 3GJ4 3GJ5 3GJ6 3GJ7 3GJ8 3GJX 3NBY 3NBZ 3NC0 3NC1 3ZJY 4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HAZ 4HB0 4HB2 4HB3 4HB4
Enriched GO Terms of Interacting Partners?		Nuclear Import Viral Process Viral Life Cycle Intracellular Transport Of Virus Mitotic Nuclear Envelope Disassembly Nucleocytoplasmic Transport Protein Export From Nucleus Nuclear Transport Nuclear Envelope Disassembly Gene Expression Nuclear Envelope Organization Glucose Transport Hexose Transport Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Viral Transcription RNA Biosynthetic Process Regulation Of Glucose Transport Positive Regulation Of Transcription, DNA-templated Nephrogenic Mesenchyme Morphogenesis Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Negative Regulation Of RNA Export From Nucleus Motor Neuron Apoptotic Process Viral Penetration Into Host Nucleus Nuclear Export MRNA Transport Protein Import Into Nucleus Nucleus Organization Carbohydrate Transport Positive Regulation Of Macromolecule Biosynthetic Process RNA Transport Positive Regulation Of Gene Expression Ribosomal Small Subunit Export From Nucleus Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis TRAIL-activated Apoptotic Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Protein Import Mitotic Cell Cycle Process Cytoplasmic Transport Defense Response To Virus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Localization To Nucleus Mitotic Cell Cycle Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process	Nucleocytoplasmic Transport Nuclear Transport Cytoplasmic Transport Intracellular Transport Protein Transport Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Protein Transport Nuclear Import Protein Localization Cellular Localization Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cellular Protein Localization Protein Import Establishment Of Protein Localization To Organelle RNA Transport RNA Localization Protein Localization To Organelle Protein Targeting Protein Export From Nucleus Nuclear Export Transport Ribosomal Protein Import Into Nucleus Positive Regulation Of Ran GTPase Activity Viral Life Cycle MRNA Transport Cellular Response To Organic Substance Mitotic Cell Cycle Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly NLS-bearing Protein Import Into Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Response To Organic Substance Regulation Of Nucleocytoplasmic Transport Cell Cycle Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Process Nuclear Envelope Organization Mitotic Cell Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Intracellular Transport Cellular Response To Transforming Growth Factor Beta Stimulus Viral Transcription
Tagcloud ?			5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Difference) ?			5a accessible actually arginine bandshift bi cargo characterised directional dissociated export exports gtpase heterodimer import imported importin localisation masks multimeric nes nls nucleoplasm overlaps rab rev rip shuttle unspliced
Tagcloud (Intersection) ?