NUP214 and PRRX2

		NUP214	PRRX2
Description		nucleoporin 214	paired related homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Cytoplasmic Side Of Nuclear Pore	Chromatin Nucleus
	Molecular Function	Nuclear Export Signal Receptor Activity Protein Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Protein Transport Regulation Of Nucleocytoplasmic Transport MRNA Transport Regulation Of Cell Cycle	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins HuR (ELAVL1) binds and stabilizes mRNA SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 31219225)	Response to exercise (triglyceride level interaction) ( 26491034)
Interacting Genes		19 interacting genes: APC CLEC4G DDX19B IPO5 NUP107 NUP42 NUP88 NXF1 NXF2 SMAD2 SMAD3 SMAD4 SUMO2 TNPO1 TSG101 XPO1 XPO5 XPOT ZFP36	1 interacting genes: SOX10
Entrez ID		8021	51450
HPRD ID		00258	05244
Ensembl ID		ENSG00000126883	ENSG00000167157
Uniprot IDs		B7ZAV2 P35658	A0A140VJS2 Q99811
PDB IDs		2OIT 3FHC 3FMO 3FMP 5DIS 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		RNA Transport Nuclear Transport Nucleocytoplasmic Transport RNA Export From Nucleus Nuclear Export Nucleobase-containing Compound Transport MRNA Transport Nuclear Pore MRNA Export From Nucleus Intracellular Transport Cellular Localization Establishment Of Localization In Cell Intracellular Protein Transport RNA Binding Nuclear Envelope Protein Transport SMAD Protein Complex Heteromeric SMAD Protein Complex Protein Localization To Nucleus Establishment Of Protein Localization Nuclear Export Signal Receptor Activity Primary MiRNA Processing Protein Import Into Nucleus Import Into Nucleus I-SMAD Binding Cytosol MRNA Binding Nuclear Localization Sequence Binding Structural Constituent Of Nuclear Pore Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Poly(A)+ MRNA Export From Nucleus Kinetochore SMAD Protein Signal Transduction R-SMAD Binding Nucleoplasm Activin Receptor Signaling Pathway Intracellular Protein Localization Establishment Of Protein Localization To Organelle Endoderm Development Protein Export From Nucleus MiRNA Processing Mesoderm Morphogenesis Pericardium Development Ribosomal Large Subunit Export From Nucleus Nucleus Trophoblast Cell Migration Ribosomal Small Subunit Export From Nucleus Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery	Response To Anesthetic Ripoptosome Embryo Development Ending In Birth Or Egg Hatching Death Effector Domain Binding Multicellular Organism Development Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development CD95 Death-inducing Signaling Complex Chordate Embryonic Development Mitochondrial Outer Membrane Lacrimal Gland Development Cellular Response To Progesterone Stimulus Cytoplasmic Side Of Nuclear Pore Death-inducing Signaling Complex Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Cell Development Self Proteolysis Response To Cobalt Ion TRAIL-activated Apoptotic Signaling Pathway Central Nervous System Myelination Negative Regulation Of Schwann Cell Proliferation Enteric Nervous System Development Nuclear Export Signal Receptor Activity Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Macrophage Differentiation Death Receptor Binding Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Digestive Tract Morphogenesis Pigment Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Glial Cell Proliferation Melanocyte Differentiation Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding Regulation Of Macrophage Differentiation Execution Phase Of Apoptosis Cell Differentiation Involved In Embryonic Placenta Development Oligodendrocyte Development Peripheral Nervous System Development DNA-binding Transcription Activator Activity Positive Regulation Of Neuroblast Proliferation Regulation Of Necroptotic Process Tumor Necrosis Factor Receptor Binding Protein Export From Nucleus Response To Progesterone Response To Lipid Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Macrophage Differentiation Regulation Of Cell Development Pyroptotic Inflammatory Response
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?