CALCR and FLNA

Number of citations of the paper that reports this interaction (PMID 12531889)
21

Data Source:
HPRD (in vivo, two hybrid)

		CALCR	FLNA
Gene Name		calcitonin receptor	filamin A, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Cytoplasm Trans-Golgi Network Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Cortical Cytoskeleton Myb Complex Neuronal Cell Body Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Apical Dendrite
	Molecular Function	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Calcitonin Binding	Glycoprotein Binding Signal Transducer Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding Ral GTPase Binding Small GTPase Binding Mu-type Opioid Receptor Binding Fc-gamma Receptor I Complex Binding Protein Homodimerization Activity Poly(A) RNA Binding SMAD Binding Rac GTPase Binding Actin Filament Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Adenylate Cyclase Activity Response To Glucocorticoid Protein Localization To Plasma Membrane	Epithelial To Mesenchymal Transition Platelet Degranulation Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Blood Coagulation Platelet Activation Actin Cytoskeleton Reorganization Cell Junction Assembly Protein Localization To Cell Surface Negative Regulation Of Protein Catabolic Process Cilium Assembly MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription Factor Import Into Nucleus Receptor Clustering Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Early Endosome To Late Endosome Transport Establishment Of Protein Localization Protein Stabilization Cytoplasmic Sequestering Of Protein Actin Crosslink Formation Platelet Aggregation Mitotic Spindle Assembly
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Cell junction organization GP1b-IX-V activation signalling Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Cell-extracellular matrix interactions
Drugs		Salmon Calcitonin Pramlintide
Diseases
GWAS		Birth weight ( 23202124)
Protein-Protein Interactions		8 interactors: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 THBS1	82 interactors: ADAMTSL4 APC AR ARHGAP24 ARRB1 ARRB2 ASB2 BRCA2 CALCR CAMK2G CASR CAV1 CCNB1 CDC42 CEACAM1 CMIP DCN DRD1 DRD2 DRD3 ERBB3 F3 FABP1 FAM101A FBLIM1 FILIP1 FLNB FURIN GP1BA GRIK1 GRIK3 GRM4 GRM5 GRM7 GRM8 HNRNPD HSPB7 ITGB1 ITGB3 ITGB5 ITGB6 ITGB7 KCNE4 KCNJ2 KLHL12 LGALS14 LMNA MAP2K4 MAPK14 MTNR1A MTNR1B MYOT NPHP1 OPRM1 PAK1 PCBP2 PRKCA PSEN1 PSEN2 RAC1 RALA REL RHOA SELE SH2B3 SHBG SIGLEC10 SMAD3 SMAD5 SRC SVIL SYNPO2 TCF4 TLR10 TNIP2 TRAF2 TRIM55 TRIO TTN USP19 VHL YWHAG
Entrez ID		799	2316
HPRD ID		00239	02060
Ensembl ID		ENSG00000004948	ENSG00000196924
Uniprot IDs		A4D1G6 P30988	P21333 Q60FE5 Q6NXF2
PDB IDs			2AAV 2BP3 2BRQ 2J3S 2JF1 2K3T 2K7P 2K7Q 2W0P 2WFN 3CNK 3HOC 3HOP 3HOR 3ISW 3RGH
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Vesicle-mediated Transport Platelet Degranulation Membrane Organization Receptor Metabolic Process Establishment Of Localization In Cell Cellular Localization Regulation Of Signal Transduction Platelet Activation Transport Endocytosis Regulation Of Signaling Receptor Internalization Negative Regulation Of Ion Transmembrane Transport Exocytosis Negative Regulation Of Transmembrane Transport Protein Localization To Membrane Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transport Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Regulation Of CAMP Biosynthetic Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Secretion By Cell Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Regulation Of Body Fluid Levels Response To Calcium Ion Intracellular Transport Wound Healing G-protein Coupled Receptor Catabolic Process Secretion Cell Activation Response To Wounding Protein Localization To Plasma Membrane Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Glycosylation G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Antigen Processing And Presentation	Signal Transduction Cellular Response To Stimulus Signaling Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Stress Regulation Of Phosphorus Metabolic Process Wound Healing Response To Wounding Regulation Of Signaling Positive Regulation Of Signal Transduction Response To Organic Substance Positive Regulation Of Metabolic Process Response To External Stimulus Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Apoptotic Process Response To Abiotic Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Regulation Of Cellular Process Positive Regulation Of Catalytic Activity Negative Regulation Of Signaling Anatomical Structure Development Positive Regulation Of Phosphorylation Tissue Development Blood Coagulation Hemostasis Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Multicellular Organismal Development System Development Cellular Response To Organic Substance Regulation Of Apoptotic Process Developmental Process
Tagcloud ?		acp5 b220 calcitonin cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Difference) ?		acp5 b220 calcitonin cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	actin acts aggregation bilateral calcineurin cortical cytoskeleton defects downregulation heterotopia isoforms knockdown lateral lining linking malformation migration periventricular ph prevented progenitor radial rcan1 rearrangement regulators shrna underlie upstream ventricles
Tagcloud (Intersection) ?