CALCR and RAMP1

Number of citations of the paper that reports this interaction (PMID 10385705)
47

Data Source:
HPRD (in vitro)

		CALCR	RAMP1
Gene Name		calcitonin receptor	receptor (G protein-coupled) activity modifying protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Calcitonin Binding	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Coreceptor Activity Calcitonin Receptor Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Adenylate Cyclase Activity Response To Glucocorticoid Protein Localization To Plasma Membrane	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Salmon Calcitonin Pramlintide	Pramlintide
Diseases
GWAS		Birth weight ( 23202124)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 THBS1	6 interactors: CALCA CALCR CALCRL IAPP SLC31A2 VIPR1
Entrez ID		799	10267
HPRD ID		00239	05515
Ensembl ID		ENSG00000004948	ENSG00000132329
Uniprot IDs		A4D1G6 P30988	E9PC20 O60894
PDB IDs			2YX8 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Vesicle-mediated Transport Platelet Degranulation Membrane Organization Receptor Metabolic Process Establishment Of Localization In Cell Cellular Localization Regulation Of Signal Transduction Platelet Activation Transport Endocytosis Regulation Of Signaling Receptor Internalization Negative Regulation Of Ion Transmembrane Transport Exocytosis Negative Regulation Of Transmembrane Transport Protein Localization To Membrane Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Transport Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Regulation Of CAMP Biosynthetic Process Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Secretion By Cell Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Regulation Of Body Fluid Levels Response To Calcium Ion Intracellular Transport Wound Healing G-protein Coupled Receptor Catabolic Process Secretion Cell Activation Response To Wounding Protein Localization To Plasma Membrane Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Positive Regulation Of Transport Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Glycosylation G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Antigen Processing And Presentation	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Internalization Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Bone Resorption Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Regulation Of Bone Remodeling Positive Regulation Of Lyase Activity Receptor-mediated Endocytosis G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Cellular Metal Ion Homeostasis Regulation Of Cyclase Activity Regulation Of Tissue Remodeling Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Sensory Perception Of Pain Feeding Behavior Ion Homeostasis Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Endocytosis Cellular Homeostasis Regulation Of Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signal Transduction Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization
Tagcloud ?		acp5 b220 calcitonin cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	adenylate autoradiography barrier bbb blockers blue calcitonin cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Difference) ?		acp5 b220 cd11b cd2 cd31 cd3e cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11	adenylate autoradiography barrier bbb blockers blue cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Intersection) ?		calcitonin