CALCR and GPRASP2

Number of citations of the paper that reports this interaction (PubMedID 15086532)
0

Data Source:
HPRD (in vitro)

		CALCR	GPRASP2
Description		calcitonin receptor	G protein-coupled receptor associated sorting protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Cilium Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3	Nucleus Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Calcitonin Binding Calcitonin Family Receptor Activity Amylin Receptor Activity	Amyloid-beta Binding G Protein-coupled Receptor Binding Protein Binding
	Biological Process	Ossification Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Negative Regulation Of Ossification Osteoclast Differentiation Regulation Of MRNA Stability Positive Regulation Of Calcium-mediated Signaling Response To Glucocorticoid Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Calcitonin Family Receptor Signaling Pathway Amylin Receptor Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Amylin Receptor 3 Signaling Pathway Response To Amyloid-beta Calcitonin Gene-related Peptide Receptor Signaling Pathway	Hematopoietic Stem Cell Homeostasis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs		Salmon calcitonin Pramlintide
Diseases
GWAS		A body shape index ( 34021172) Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 25760438 28448500 28892062) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Cutaneous leishmaniasis ( 32830257) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Type 2 diabetes ( 32499647) Weight ( 28552196)
Interacting Genes		9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1	52 interacting genes: ADRB1 ARHGEF6 BARD1 CALCR CAVIN3 CBX8 CCDC146 CEP126 CFAP206 CHRM1 CHRM2 DISC1 DSCR9 EFCAB3 FAM124B FCHSD2 FOXD4L1 FRAT1 GADD45GIP1 HAP1 HRH2 HTR7 HTT LRIF1 MBD3L2 MICU2 MYOT NOL4L-DT PIH1D2 PLAC9 PRPF3 PTN RABGEF1 REX1BD RHPN1 RNF8 RPS6KA5 SAPCD2 SEZ6L SH2D4A SREK1 STMN2 TBRG4 TCF25 TSPOAP1 TTC23 TXN TXN2 USP20 ZC2HC1C ZFYVE26 ZNF688
Entrez ID		799	114928
HPRD ID		00239	06612
Ensembl ID		ENSG00000004948	ENSG00000158301
Uniprot IDs		A0A0A0MSQ7 P30988	B3KW05 Q96D09
PDB IDs		5II0 5UZ7 6NIY 6PFO 6PGQ 7TYF 7TYH 7TYI 7TYL 7TYN 7TYO 7TYW 7TYX 7TYY 7TZF 8F0J 8F0K 8F2A 8F2B 9AUC
Enriched GO Terms of Interacting Partners?		Amylin Receptor Activity Amylin Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Protein Activation Cascade Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Vesicle-mediated Transport Protein Localization To Plasma Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Protein Localization To Cell Periphery Calcium Ion Transport Protein Sequestering Activity Cell Surface G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Sperm Midpiece Sarcomere Regulation Of Action Potential Regulation Of Signaling Establishment Of Localization In Cell Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Protein Maturation Cellular Localization Protein Localization To Membrane Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Localization To Plasma Membrane Calcitonin Gene-related Peptide Binding Coreceptor Activity Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Receptor Internalization G Protein-coupled Receptor Binding Calcium-dependent Protein Binding Positive Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Cell Communication Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Signaling Regulation Of Calcium-mediated Signaling Negative Regulation Of Nitric Oxide Mediated Signal Transduction Collagen V Binding Brown Fat Cell Proliferation Amphisome Positive Regulation Of Protein Localization To Membrane G Protein-coupled Receptor Catabolic Process CGRP Receptor Complex Amyloid-beta Binding Amylin Receptor Complex 3 Signal Transduction Endocytosis	G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Trans-synaptic Signaling G Protein-coupled Acetylcholine Receptor Activity Synaptic Signaling Neuromuscular Synaptic Transmission Regulation Of Protein Export From Nucleus Negative Regulation Of Protein Export From Nucleus Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Microtubule Cytoskeleton Organization Cholinergic Synapse Dendrite
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