MCMBP and PRTFDC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid)

		MCMBP	PRTFDC1
Name		minichromosome maintenance complex binding protein	phosphoribosyl transferase domain containing 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Cytosol
	Molecular Function	Chromatin Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process
GWAS		Body size at age 10 ( 32376654 ) Height ( 28552196 )	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Diisocyanate-induced asthma ( 25918132 ) Eosinophil count ( 32888494 ) Granulocyte count ( 27863252 ) High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Intraocular pressure ( 29617998 ) Lymphocyte count ( 27863252 32888494 ) Metabolite levels (Pyroglutamine) ( 23934736 ) Monocyte count ( 32888494 27863252 ) Myeloid white cell count ( 27863252 ) Neutrophil count ( 32888494 27863252 ) Obesity-related traits ( 23251661 ) Perceived intensity of neohesperidin dihydrochalcone ( 31005972 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Post-traumatic stress disorder ( 25456346 ) Red cell distribution width ( 27863252 32888494 ) Reticulocyte count ( 32888494 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) White blood cell count ( 27863252 32888494 )
Interacting Genes		14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	19 interacting genes: - CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SPG21 STAT5A TCL1A TMEM14B VWA5A
Entrez ID		79892	56952
HPRD ID		07624	17917
Ensembl ID		ENSG00000197771	ENSG00000099256
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	Q9NRG1
PDB IDs		4KG9	2JBH
GO Terms Enriched among Interactors		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body	None