MCMBP and ASL

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid)

		MCMBP	ASL
Name		minichromosome maintenance complex binding protein	argininosuccinate lyase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding	Catalytic Activity Argininosuccinate Lyase Activity Protein Binding Lyase Activity Identical Protein Binding
	Biological Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division	Urea Cycle Amino Acid Metabolic Process Arginine Metabolic Process L-arginine Biosynthetic Process Locomotory Behavior Amino Acid Biosynthetic Process Post-embryonic Development Ammonia Assimilation Cycle L-arginine Biosynthetic Process Via Ornithine Positive Regulation Of Nitric Oxide Biosynthetic Process L-amino Acid Metabolic Process
Pathways		None	Urea cycle
Drugs		None	Arginine Argininosuccinate 2-(N-morpholino)ethanesulfonic acid
Diseases		None	Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency
GWAS		Body size at age 10 ( 32376654 ) Height ( 28552196 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	10 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2 TRIM3
Entrez ID		79892	435
HPRD ID		07624	01948
Ensembl ID		ENSG00000197771	ENSG00000126522
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	A0A024RDL8 A0A0S2Z316 P04424
PDB IDs		4KG9	1AOS 1K62
GO Terms Enriched among Interactors		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body	Protein Serine Kinase Activity Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catabolic Process Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Perivitelline Space Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Protein Kinase CK2 Complex Cellular Hypotonic Salinity Response Cytosol Cellular Response To Cisplatin Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Nuclear Speck Organization