MCMBP and DBF4

Number of citations of the paper that reports this interaction (PubMedID 22540012)
54

Data Source:
BioGRID (two hybrid)

		MCMBP	DBF4
Description		minichromosome maintenance complex binding protein	DBF4-CDC7 kinase regulatory subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex	Nucleus Nucleoplasm Nuclear Body Dbf4-dependent Protein Kinase Complex
	Molecular Function	Chromatin Binding Protein Binding	Nucleic Acid Binding Protein Binding Enzyme Activator Activity Zinc Ion Binding Protein Serine/threonine Kinase Activator Activity Metal Ion Binding
	Biological Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division	G1/S Transition Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Phase Transition
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Height ( 28552196)	Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474	19 interacting genes: BRCA1 CDC7 CDK2 CHAF1A CHEK1 CHEK2 LSM8 MCM2 MCM3 MCM4 MCM6 MCM7 MCMBP MEN1 ORC1 ORC2 ORC3 ORC5 ORC6
Entrez ID		79892	10926
HPRD ID		07624	10371
Ensembl ID		ENSG00000197771	ENSG00000006634
Uniprot IDs		A0A0S2Z5P5 Q9BTE3	B4DXK0 B7Z8C6 Q9UBU7
PDB IDs		4KG9	4F99 4F9A 4F9B 4F9C 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body	DNA Replication DNA Replication Initiation DNA Metabolic Process Chromosome, Telomeric Region Nucleic Acid Metabolic Process Nuclear Origin Of Replication Recognition Complex Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Replication Origin Recognition Complex Regulation Of DNA-templated DNA Replication Initiation DNA Repair CMG Complex Regulation Of DNA Metabolic Process DNA Damage Response DNA Replication Origin Binding Macromolecule Metabolic Process Nucleoplasm Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Mitotic DNA Replication Initiation Nucleus Cellular Response To Stress Mitotic DNA Integrity Checkpoint Signaling Chromosome ATP Binding DNA Helicase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle G2/M Phase Transition Helicase Activity Nucleotide Binding DNA Strand Elongation Involved In DNA Replication Mitotic DNA Damage Checkpoint Signaling DNA Strand Elongation Negative Regulation Of Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process ATP Hydrolysis Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Phase Transition Chromatin Negative Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Response To Stress
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