RPAP2 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RPAP2	PLEKHF2
Description		RNA polymerase II associated protein 2	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Transcription Preinitiation Complex	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Zinc Ion Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity RNA Polymerase Core Enzyme Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II SnRNA Transcription PERK-mediated Unfolded Protein Response	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte count ( 32888494) Monocyte count ( 27863252) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 27863252 32888494) Type 1 diabetes ( 34127860)	Radiation response ( 20923822)
Interacting Genes		3 interacting genes: ITCH NEDD4 PLEKHF2	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		79871	79666
HPRD ID		07814	15147
Ensembl ID		ENSG00000122484	ENSG00000175895
Uniprot IDs		Q8IXW5	Q9H8W4
PDB IDs		7B7U 7F4G
Enriched GO Terms of Interacting Partners?		Receptor Internalization Protein K63-linked Ubiquitination Protein Monoubiquitination Cell Cortex Channel Inhibitor Activity Vesicle-mediated Transport Vacuolar Transport Lysosomal Transport Receptor-mediated Endocytosis Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Positive Regulation Of Protein Catabolic Process Intracellular Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane T Cell Activation Early Endosome Membrane Early Endosome Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Sodium Channel Inhibitor Activity Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy C-X-C Chemokine Receptor CXCR4 Signaling Pathway Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endocytosis Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Endocardial Cushion Development Lymphocyte Activation Potassium Channel Inhibitor Activity Positive Regulation Of Tolerance Induction Regulation Of Protein Deubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Protein K29-linked Ubiquitination CXCR Chemokine Receptor Binding Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Tolerance Induction	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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