RPAP2

Name	RNA polymerase II associated protein 2
Structure
Interactors	3 interactors: ITCH NEDD4 PLEKHF2
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cilium Transcription Preinitiation Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Zinc Ion Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Hydrolase Activity RNA Polymerase Core Enzyme Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II SnRNA Transcription PERK-mediated Unfolded Protein Response
Pathways	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
GWAS	Granulocyte percentage of myeloid white cells ( 27863252 ) Lymphocyte count ( 32888494 ) Monocyte count ( 27863252 ) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376 ) Neutrophil percentage of white cells ( 27863252 32888494 ) Type 1 diabetes ( 34127860 )
Entrez ID	79871
HPRD ID	07814
Ensembl ID	ENSG00000122484
Uniprot IDs	Q8IXW5
PDB IDs	7B7U 7F4G
GO Terms Enriched among Interactors ?	Receptor Internalization Protein K63-linked Ubiquitination Protein Monoubiquitination Cell Cortex Channel Inhibitor Activity Vesicle-mediated Transport Vacuolar Transport Lysosomal Transport Receptor-mediated Endocytosis Formation Of Structure Involved In A Symbiotic Process Protein Polyubiquitination Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Positive Regulation Of Protein Catabolic Process Intracellular Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane T Cell Activation Early Endosome Membrane Early Endosome Positive Regulation Of T Cell Anergy CXCL12-activated CXCR4 Signaling Pathway T Cell Tolerance Induction T Cell Anergy Sodium Channel Inhibitor Activity Regulation Of Protein Catabolic Process Ubiquitin Protein Ligase Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Regulation Of T Cell Anergy C-X-C Chemokine Receptor CXCR4 Signaling Pathway Positive Regulation Of Receptor Catabolic Process CD4-positive, Alpha-beta T Cell Proliferation Arrestin Family Protein Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Endocytosis Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Endocardial Cushion Development Lymphocyte Activation Potassium Channel Inhibitor Activity Positive Regulation Of Tolerance Induction Regulation Of Protein Deubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Protein K29-linked Ubiquitination CXCR Chemokine Receptor Binding Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Tolerance Induction