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ZBTB3 and THRA
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
ZBTB3
THRA
Gene Name
zinc finger and BTB domain containing 3
thyroid hormone receptor, alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleus
Nucleoplasm
Cytosol
Molecular Function
DNA Binding
Metal Ion Binding
Steroid Receptor RNA Activator RNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Thyroid Hormone Receptor Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
TBP-class Protein Binding
Protein Domain Specific Binding
Chromatin DNA Binding
Protein Complex Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Thyroid Hormone Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Cartilage Condensation
Ossification
Regulation Of Thyroid Hormone Mediated Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Learning Or Memory
Regulation Of Heart Contraction
Female Courtship Behavior
Response To Cold
Hormone-mediated Signaling Pathway
Gene Expression
Positive Regulation Of Myotube Differentiation
Negative Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly
Erythrocyte Differentiation
Intracellular Receptor Signaling Pathway
Thyroid Gland Development
Regulation Of Myeloid Cell Apoptotic Process
Cytoplasmic Sequestering Of Transcription Factor
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Female Receptivity
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Lipid Catabolic Process
Type I Pneumocyte Differentiation
Negative Regulation Of DNA-templated Transcription, Initiation
Pathways
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Drugs
Liothyronine
Levothyroxine
Dextrothyroxine
Liotrix
3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid
Diseases
GWAS
White blood cell count (
21738480
)
Protein-Protein Interactions
21 interactors:
ANKRD2
BIN1
EIF5B
FOXM1
GATA4
GTF2A1L
IKBKG
IRF6
JADE2
LEF1
NR3C1
PKNOX1
PPARG
PROX1
SKIL
SMAD3
SSX3
SUPT5H
THRA
ZMYM2
ZNF556
56 interactors:
AKAP13
AMOTL2
ARID5A
BTG1
BUB3
C1D
CCND1
CDK7
CLIC1
COPS2
CREB1
CREBBP
CUL1
DAP3
ESR1
FOXJ1
FUS
GRIP1
GTF2B
HDAC2
HDAC3
ITGB3BP
L3MBTL3
MED1
MED21
MED25
MEF2A
NCOA1
NCOA6
NCOR1
NCOR2
NR0B2
NR2F1
NRIP1
NSD1
OASL
PML
POU2F1
PRKDC
PTGES3
RANBP9
RGN
RXRA
RXRB
RXRG
SEPP1
SLC16A2
SRC
SUV39H1
TBL1X
TDG
TRIM24
TRIP11
YWHAH
YWHAQ
ZBTB3
Entrez ID
79842
7067
HPRD ID
15693
07185
Ensembl ID
ENSG00000185670
ENSG00000126351
Uniprot IDs
Q9H5J0
P10827
Q6FH41
PDB IDs
1NAV
2H77
2H79
3HZF
3ILZ
3JZB
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Gene Expression
Transcription From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Nitrogen Compound Metabolic Process
Epithelial Cell Differentiation
DNA-templated Transcription, Initiation
Nitrogen Compound Metabolic Process
Epithelium Development
Gland Development
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Cell Differentiation
Regulation Of Cellular Process
Tissue Development
Positive Regulation Of Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Organ Development
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Lens Fiber Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Cell Development
Muscle Structure Development
Negative Regulation Of Cellular Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
RNA Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Intracellular Receptor Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cellular Metabolic Process
DNA-templated Transcription, Initiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Cellular Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Nitrogen Compound Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Rhythmic Process
Organ Development
Multicellular Organismal Development
Regulation Of Cellular Process
Anatomical Structure Development
Developmental Process
Cellular Response To Organic Substance
Signal Transduction
Chromosome Organization
Signaling
System Development
Tagcloud
?
accounts
averages
bimodality
bxd
bxh
chr
counted
encode
ganglion
heritable
hoxb
idea
inbred
krt1
lod
mapped
neuregulin
nnc1
opposed
qtl
qtls
retina
retinal
striking
subsidiary
surprisingly
thyroxine
trait
vertebrate
Tagcloud (Difference)
?
accounts
averages
bimodality
bxd
bxh
chr
counted
encode
ganglion
heritable
hoxb
idea
inbred
krt1
lod
mapped
neuregulin
nnc1
opposed
qtl
qtls
retina
retinal
striking
subsidiary
surprisingly
thyroxine
trait
vertebrate
Tagcloud (Intersection)
?