ZBTB3 and IRF6

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZBTB3	IRF6
Gene Name		zinc finger and BTB domain containing 3	interferon regulatory factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Metal Ion Binding	Regulatory Region DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Transcription, DNA-templated Cell Cycle Arrest Negative Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Cell Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation
Pathways			Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Cleft lip ( 20436469) Orofacial clefts ( 19270707 22863734)
Protein-Protein Interactions		21 interactors: ANKRD2 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SSX3 SUPT5H THRA ZMYM2 ZNF556	5 interactors: IRF8 LBP RFX3 TLX2 ZBTB3
Entrez ID		79842	3664
HPRD ID		15693	06227
Ensembl ID		ENSG00000185670	ENSG00000117595
Uniprot IDs		Q9H5J0	G0Z349 O14896
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Epithelium Development Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Cellular Process Tissue Development Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organ Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Steroid Hormone Mediated Signaling Pathway Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Development Muscle Structure Development Negative Regulation Of Cellular Metabolic Process	Negative Regulation Of Growth Of Symbiont In Host Cellular Response To Lipopolysaccharide Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Type B Pancreatic Cell Maturation Lipopolysaccharide Transport Transcription, DNA-templated Cellular Response To Molecule Of Bacterial Origin RNA Biosynthetic Process Defense Response To Bacterium Cilium-dependent Cell Motility Positive Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Growth Phagocytosis Glandular Epithelial Cell Maturation Positive Regulation Of Toll-like Receptor 4 Signaling Pathway RNA Metabolic Process Positive Regulation Of Respiratory Burst Response To Lipopolysaccharide Negative Regulation Of Dendrite Morphogenesis Response To Molecule Of Bacterial Origin Gene Expression Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Or Flagellum-dependent Cell Motility Positive Regulation Of Cytokine Production Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Opsonization Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Positive Regulation Of Macrophage Activation Macromolecule Biosynthetic Process Positive Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Type B Pancreatic Cell Development Positive Regulation Of DNA-templated Transcription, Initiation Enteric Nervous System Development Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Cellular Response To Lipid Regulation Of Metabolic Process Negative Regulation Of Dendrite Development Type B Pancreatic Cell Development Leukocyte Migration Involved In Inflammatory Response Regulation Of DNA-templated Transcription, Initiation Response To Bacterium Defense Response To Protozoan Regulation Of Tumor Necrosis Factor Biosynthetic Process
Tagcloud ?			cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Difference) ?			cd68 conceptus coordinately dialogue enjsrv ensures env estrous ewes exosomal exosomes flushings hsc70 ifnt interleukins irak1 irf7 jaagsiekte liberated oftlr otr1 ovine plasmacytoid proliferated retroviruses ruminants tlr trophectoderm uterine
Tagcloud (Intersection) ?