ZBTB3 and SUPT5H

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZBTB3	SUPT5H
Description		zinc finger and BTB domain containing 3	SPT5 homolog, DSIF elongation factor subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Elongation Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Positive Regulation Of Macroautophagy Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ANKRD2 AP1M1 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 MYO15B NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SMYD1 SSX3 SUPT5H THRA ZMYM2 ZNF556	51 interacting genes: C9orf78 CCNH CCNT2 CDK7 CDK9 CEP55 CPSF7 CSNK2A1 DBN1 DCAF6 DSCAM EXOSC7 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PGK1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 RPL9 SAP30BP SIK1 SNRNP48 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 YBX2 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		79842	6829
HPRD ID		15693	03655
Ensembl ID		ENSG00000185670	ENSG00000196235
Uniprot IDs		A0A6E1W9L1	O00267
PDB IDs			2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED 7OKX 7OKY 7OL0 7PKS 7UNC 7UND 7YCX 8A3Y 8P4C 8P4D 8P4E 8P4F 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 8W8F 9EGX 9EGY 9EGZ 9EH0 9EH2 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Epithelial Cell Differentiation Animal Organ Development Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process DNA Binding Domain Binding Positive Regulation Of Biosynthetic Process DNA-templated Transcription Myeloid Cell Differentiation Cell Differentiation DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Regulator Complex Gland Development Transdifferentiation LBD Domain Binding Chromatin Binding Tube Morphogenesis	Nucleus Nucleic Acid Metabolic Process Transcription Factor TFIIK Complex CAK-ERCC2 Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Regulation Of RNA Metabolic Process DNA-templated Transcription Initiation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Transcription Factor TFIIH Holo Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Gene Expression Transcription Elongation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Regulation Of Macromolecule Metabolic Process DNA-templated Transcription Elongation Protein Peptidyl-prolyl Isomerization Chromosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Chromosome Segregation DNA Metabolic Process Recombinational Repair Protein Localization To Site Of Double-strand Break Protein Binding DNA Recombination Transcription Pausing By RNA Polymerase II Postsynaptic Cytosol Histone H4R3 Methyltransferase Activity Peptidyl-arginine Methylation DNA Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Anoikis Regulation Of Transcription Elongation By RNA Polymerase II Transcription Elongation-coupled Chromatin Remodeling Macromolecule Biosynthetic Process
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