ZBTB3 and GATA4

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZBTB3	GATA4
Gene Name		zinc finger and BTB domain containing 3	GATA binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Metal Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction
Pathways			Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS			Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		21 interactors: ANKRD2 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SSX3 SUPT5H THRA ZMYM2 ZNF556	23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2
Entrez ID		79842	2626
HPRD ID		15693	08994
Ensembl ID		ENSG00000185670	ENSG00000136574
Uniprot IDs		Q9H5J0	B3KUF4 B7ZKZ4 P43694
PDB IDs			2M9W
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Epithelial Cell Differentiation DNA-templated Transcription, Initiation Nitrogen Compound Metabolic Process Epithelium Development Gland Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Differentiation Regulation Of Cellular Process Tissue Development Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organ Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Steroid Hormone Mediated Signaling Pathway Lens Fiber Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Development Muscle Structure Development Negative Regulation Of Cellular Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis
Tagcloud ?			6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Difference) ?			6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Intersection) ?